No full text
Poster (Scientific congresses and symposiums)
A rapid immunochromatographic test (ICT) for serological diagnosis of tuberculosis
Hayette, Marie-Pierre; Serpe, K.; Gonissen, Viviane et al.
199811ème réunion scientifique


Full Text
No document available.

Send to


Keywords :
ICT; tuberculosis; diagnosis; infection; serology; rapid test
Abstract :
[en] The lCT tuberculosis is an in vitro immunodiagnostic test for the detection of antibodies to Mycobacterium tuberculosis in serum or plasma. This test targets 5 recombinant M tuberculosis proteins, including the 38 and 85 KDa antigens. We evaluated this test on 65 sera from patients with and without TB living in Liege. Patients and methods: This test was performed on two groups : The TB group included 31 patients condidered to have an active tuberculosis : pulmonary (26 cases) or extrapulmonary (5 cases). All of them had at least one sample with positive culture and received anti-tuberculous treatment. The identification of TB strains was performed with Accuprobe M tuberculosis complexe (Gen-Probe). The second group (control group) included 34 patients with the following characteristics: BCG negative nonexposed healthy (19), BCG positive or exposed healthy (2), non-TB respiratory disease (10), atypical TB (3). The identification of the atypical mycobacteria was determined according to the biochemical characteristics or by molecular biology. Results. The sensitivity is 38.7%, the specificity is 94%. The positive predictive value is 85.7% and the negative predictive value is 62,7%. Two false lCT positive results were found in the control group: both patients had a past infection with TB. Conclusion: This test is very easy and rapid to perform, has a good specificity but lacks sensitivity in low prevalence countries. A positive lCT allows same day diagnosis of Mycobacterium tuberculosis infection.
Disciplines :
Immunology & infectious disease
Laboratory medicine & medical technology
Author, co-author :
Hayette, Marie-Pierre ;  Université de Liège - ULiège > Microbiologie médicale
Serpe, K.;  Clinique André Renard, Hertsal > Laboratoire
Gonissen, Viviane;  Hopital du Bois de l'Abbaye, Seraing > Laboratoire
Grosjean, Y.;  Hopital La Tourelle, Verviers > Laboratoire
Carpentier, Michel;  Centre Hospitalier Régionale de la Citadelle (Liège) - CHR CITADELLE > Laboratoire > Microbiologie médicale
Rousseaux, Danielle
De Mol, Patrick ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale
Language :
Title :
A rapid immunochromatographic test (ICT) for serological diagnosis of tuberculosis
Alternative titles :
[fr] Test immuchromatographique rapide pour le diagnostic sérologique de la tuberculose
Publication date :
28 November 1998
Number of pages :
Event name :
11ème réunion scientifique
Event organizer :
Société belge d'infectiologie et de microbiologie clinique
Event place :
Gand (UZ), Belgium
Event date :
28 novembre 1998
Available on ORBi :
since 31 December 2010


Number of views
456 (7 by ULiège)
Number of downloads
0 (0 by ULiège)


Similar publications

Contact ORBi