Reference : A rapid immunochromatographic test (ICT) for serological diagnosis of tuberculosis
Scientific congresses and symposiums : Poster
Human health sciences : Laboratory medicine & medical technology
Human health sciences : Immunology & infectious disease
A rapid immunochromatographic test (ICT) for serological diagnosis of tuberculosis
[fr] Test immuchromatographique rapide pour le diagnostic sérologique de la tuberculose
Hayette, Marie-Pierre mailto [Université de Liège - ULiège > > Microbiologie médicale >]
Serpe, K. [Clinique André Renard, Hertsal > Laboratoire > > >]
Gonissen, Viviane [Hopital du Bois de l'Abbaye, Seraing > Laboratoire > > >]
Grosjean, Y. [Hopital La Tourelle, Verviers > Laboratoire > > >]
Carpentier, Michel [Centre Hospitalier Régionale de la Citadelle (Liège) - CHR CITADELLE > Laboratoire > Microbiologie médicale > >]
Rousseaux, Danielle [ > > ]
De Mol, Patrick mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale >]
11ème réunion scientifique
28 novembre 1998
Société belge d'infectiologie et de microbiologie clinique
Gand (UZ)
[en] ICT ; tuberculosis ; diagnosis ; infection ; serology ; rapid test
[en] The lCT tuberculosis is an in vitro immunodiagnostic test for the detection of
antibodies to Mycobacterium tuberculosis in serum or plasma. This test targets 5
recombinant M tuberculosis proteins, including the 38 and 85 KDa antigens. We
evaluated this test on 65 sera from patients with and without TB living in Liege.
Patients and methods: This test was performed on two groups : The TB group included
31 patients condidered to have an active tuberculosis : pulmonary (26 cases) or extrapulmonary (5 cases). All of them had at least one sample with positive culture and
received anti-tuberculous treatment. The identification of TB strains was performed
with Accuprobe M tuberculosis complexe (Gen-Probe). The second group (control
group) included 34 patients with the following characteristics: BCG negative nonexposed
healthy (19), BCG positive or exposed healthy (2), non-TB respiratory
disease (10), atypical TB (3). The identification of the atypical mycobacteria was
determined according to the biochemical characteristics or by molecular biology.
Results. The sensitivity is 38.7%, the specificity is 94%. The positive predictive value is 85.7%
and the negative predictive value is 62,7%. Two false lCT positive results were found
in the control group: both patients had a past infection with TB.
Conclusion: This test is very easy and rapid to perform, has a good specificity but
lacks sensitivity in low prevalence countries. A positive lCT allows same day
diagnosis of Mycobacterium tuberculosis infection.

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