Reference : A New Route for the Synthesis of [18f]Fluoroaromatic Substituted Amino Acids: No Carr...
Scientific journals : Article
Human health sciences : General & internal medicine
A New Route for the Synthesis of [18f]Fluoroaromatic Substituted Amino Acids: No Carrier Added L-P-[18f]Fluorophenylalanine
Lemaire, Christian mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Guillaume, M. [> > > >]
Christiaens, Léon mailto [Université de Liège - ULiège > Services généraux (Faculté des sciences) > Relations académiques et scientifiques (Sciences) >]
Palmer, A. J. [> > > >]
Cantineau, R. [> > > >]
International Journal of Radiation Applications and Instrumentation. Part A : Applied Radiation and Isotopes
Yes (verified by ORBi)
[en] L-p-[18F]fluorophenylalanine was designed as a potential marker for probing protein synthesis in the human brain by positron emission tomography. This radiotracer has been synthesized using nucleophilic displacement of the activated nitro group of p-nitrobenzaldehyde by NCA 18F- obtained from the 18O (p, n) reaction on enriched water. The L-form of the [18F]fluoroamino acid can be separated on an analytical scale chiral column. A typical production run of 22.2 GBq (600 mCi) of 18F obtained after a 10 microA.h bombardment of 18 MeV protons on 99.8% 18O-enriched water leads to a batch of 1.11 GBq (30 mCi) of NCA L-p-[18F]fluorophenylalanine after a total synthesis time of 120 min.

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