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Article (Scientific journals)
A New Route for the Synthesis of [18f]Fluoroaromatic Substituted Amino Acids: No Carrier Added L-P-[18f]Fluorophenylalanine
Lemaire, Christian; Guillaume, Marcel; Christiaens, Léon et al.
1987In International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes, 38 (12), p. 1033-8
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Abstract :
[en] L-p-[18F]fluorophenylalanine was designed as a potential marker for probing protein synthesis in the human brain by positron emission tomography. This radiotracer has been synthesized using nucleophilic displacement of the activated nitro group of p-nitrobenzaldehyde by NCA 18F- obtained from the 18O (p, n) reaction on enriched water. The L-form of the [18F]fluoroamino acid can be separated on an analytical scale chiral column. A typical production run of 22.2 GBq (600 mCi) of 18F obtained after a 10 microA.h bombardment of 18 MeV protons on 99.8% 18O-enriched water leads to a batch of 1.11 GBq (30 mCi) of NCA L-p-[18F]fluorophenylalanine after a total synthesis time of 120 min.
Disciplines :
General & internal medicine
Author, co-author :
Lemaire, Christian ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Guillaume, Marcel ;  Université de Liège - ULiège > Département de physique > Spectroscopie atomique et Physique des atomes froids
Christiaens, Léon ;  Université de Liège - ULiège > Services généraux (Faculté des sciences) > Relations académiques et scientifiques (Sciences)
Palmer, Anthony ;  Université de Liège - ULiège > Unités de recherche interfacultaires > GIGA-CRC In vivo Imaging (Centre de Recherche du Cyclotron)
Cantineau, Robert ;  Université de Liège - ULiège > Unités de recherche interfacultaires > GIGA-CRC In vivo Imaging (Centre de Recherche du Cyclotron)
Language :
English
Title :
A New Route for the Synthesis of [18f]Fluoroaromatic Substituted Amino Acids: No Carrier Added L-P-[18f]Fluorophenylalanine
Publication date :
1987
Journal title :
International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes
ISSN :
0883-2889
Publisher :
Pergamon Press, United Kingdom
Volume :
38
Issue :
12
Pages :
1033-8
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 26 November 2010

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