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Les etats preleucemiques: d'un modele experimental murin aux syndromes myelodysplasiques humains
Defresne, Marie-Paule
2001In Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique, 156 (1-2), p. 99-104, discussion 105-6
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Abstract :
[en] Using a model of experimental leukemia in mice, we have demonstrated that tumor development depends upon interactions between preleukemic cells and their microenvironment whose functions are altered. Cytokine injections inhibit tumor development by inducing a functional restoration of this environment. Human myelodysplastic syndromes (MDS) are marrow pathologies considered as preleukemic stages. As in murine leukemias, it is possible that marrow environment could play a key role in their evolution. We currently establish a model of human hematopoiesis in NOD/SCID mice grafted with human bone fragments. We hope that this model would allow to analyse the role of the marrow stromal cells in MDS and to establish treatments restoring their functions.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Defresne, Marie-Paule ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Language :
French
Title :
Les etats preleucemiques: d'un modele experimental murin aux syndromes myelodysplasiques humains
Alternative titles :
[en] Preleukemic States: An Experimental Murine Model for Myelodysplastic Human Syndromes
Publication date :
2001
Journal title :
Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique
ISSN :
0377-8231
Publisher :
Academie Royale de Médecine de Belgique, Bruxelles, Belgium
Volume :
156
Issue :
1-2
Pages :
99-104, discussion 105-6
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 15 November 2010

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