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Contribution à l’étude de la forme africaine du coryza gangreneux induite par l’herpèsvirus alcélaphin 1
Dewals, Benjamin G
2003
 

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Abstract :
[en] Malignant catarrhal fever (MCF) is an usually lethal pathology which has been described in a large number of ruminant species. Based on the etiology, two main forms of MCF have been described, i.e., the European and the African forms due to ovine herpesvirus 2 (OvHV-2) and alcelaphine herpesvirus 1 (AlHV-1), respectively. The present study was devoted to the African form of MCF (AF-MCF) and to its causative agent AlHV-1. AlHV-1 belongs to the Gammaherpesvirinae subfamily of the Herpesviridae family. Wildebeests (Connochaetes spp) carry AlHV-1, which is lethal for a large number of ruminant species, while apparently harmless to its natural host. Here, we first reproduced AF-MCF using the rabbit as animal model. Macroscopic and microscopic lesions induced by AlHV-1 infection were characteristic of AF-MCF described in cattle. Next, we undertook the cloning of AlHV-1 genome as an bacterial artificial chromosome (BAC). The molecular tools required were produced. They should allow the production of a AlHV-1-BAC shortly. The rabbit animal model together with the BAC technology will allow further studies to address AF-MCF pathogenesis.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Dewals, Benjamin G  ;  Université de Liège - ULiège
Language :
French
Title :
Contribution à l’étude de la forme africaine du coryza gangreneux induite par l’herpèsvirus alcélaphin 1
Alternative titles :
[en] Study of the African form of malignant catarrhal fever induced by alcelaphine herpesvirus 1
Defense date :
19 September 2003
Institution :
ULiège - Université de Liège
Promotor :
Vanderplasschen, Alain ;  Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Santé publique vétérinaire
Jury member :
Lekeux, Pierre ;  Université de Liège - ULiège > Département des sciences fonctionnelles (DSF)
Desmecht, Daniel ;  Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Santé publique vétérinaire
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
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since 23 February 2010

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