Efficiency of 5-Hydroxytryptamine Receptor Blockade as Therapeutic Measure During Acute Respiratory Distress Syndrome in Double-Muscled Cattle

Genicot, Bruno; Mouligneau, Frédéric; Lindsey, J. K.; Lambert, Philippe; Close, Roland; Lekeux, Pierre

doi:10.1111/j.1439-0442.1993.tb00615.x

Reference : Efficiency of 5-Hydroxytryptamine Receptor Blockade as Therapeutic Measure During Acu...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Veterinary medicine & animal health
	To cite this reference:	http://hdl.handle.net/2268/6476

Title :	Efficiency of 5-Hydroxytryptamine Receptor Blockade as Therapeutic Measure During Acute Respiratory Distress Syndrome in Double-Muscled Cattle
Language :	English
Author, co-author :	Genicot, Bruno [Université de Liège - ULiège > Faculty of Veterinary Medicine > Laboratory for Functional Investigation > >]
	Mouligneau, Frédéric [Université de Liège - ULiège > Faculty of Veterinary Medicine > Laboratory for Functional Investigation > > >]
	Lindsey, J. K. [Université de Liège - ULiège > Faculty of Veterinary Medicine > Laboratory for Functional Investigation > > >]
	Lambert, Philippe [Université de Liège - ULiège > Faculty of Veterinary Medicine > Laboratory for Functional Investigation > >]
	Close, Roland [Université de Liège - ULiège > Faculty of Veterinary Medicine > Laboratory for Functional Investigation > >]
	Lekeux, Pierre [Université de Liège - ULiège > Faculty of Veterinary Medicine > Laboratory for Functional Investigation > >]
Publication date :	Apr-1993
Journal title :	Zentralblatt für Veterinarmedizin. Reihe A
Publisher :	Verlag Paul Parey
Volume :	40
Issue/season :	3
Pages :	185-193
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0514-7158
City :	Berlin
Country :	Germany
Keywords :	[en] Respiratory distress ; cattle
Abstract :	[en] During this investigation, which involved 58 Belgian White and Blue double-muscled calves affected by a naturally occurring Acute Respiratory Distress Syndrome, the clinical efficiency of a 5-HT2 receptor blockade with metrenperone (group A) was compared to the efficiency of a non-steroidal (flunixine meglumine--group B) and a steroidal (prednisolone sodium succinate--group C) antiinflammatory drug. Each animal of this trial was treated with ceftiofur sodium as antimicrobial agent. A clinical score and a breathing score were calculated at each step of the investigation period, i.e. before (T0) and 1 hour (T1), 12 hours (H), 24 H, 48H and 168 H (T3) after the first treatment, the interval 12H-48H being considered as period T2. Three clinical parameters were also taken into account separately: rectal and peripheral temperatures and heart rate. A significant improvement of the clinical score was registered at T2 in group A and at T3 in groups A and B, while this score did not significantly change in group C. In group A, the breathing score was significantly improved at T2 and T3, but not in groups B and C. Peripheral and rectal temperatures recorded at T1 were, in group A, significantly increased and decreased respectively, but not significantly changed in groups B and C. The proportions requiring change of treatment during the investigation period were significantly (P = 0.022) different in the three groups, being 5.6, 21.4 and 50.0% in groups A, B and C respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Target :	Researchers ; Professionals ; Students
Permalink :	http://hdl.handle.net/2268/6476
DOI :	10.1111/j.1439-0442.1993.tb00615.x

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