[en] Studied prediction of progression rates of Alzheimer's disease (AD) in a prospective multicenter cohort study of 186 patients (mean age 63.2 yrs) with possible or probable AD, mostly with presenile onset. In a cross-sectional analysis at entry, impairment of glucose metabolism in temporoparietal or frontal association areas measured with positron emission tomography was significantly associated with dementia severity, clinical classification as possible vs probable AD, presence of multiple cognitive deficits and history of progression. A prospective longitudinal analysis showed a significant association between initial metabolic impairment and subsequent clinical deterioration. In patients with mild cognitive deficits at entry, the risk of deterioration was up to 4.7 times higher if the metabolism was severely impaired than with mild or absent metabolic impairment.
Disciplines :
Neurology Neurosciences & behavior
Author, co-author :
Herholz, K.
Nordberg, A.
Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Perani, D.
Kessler, J.
Mielke, R.
Halber, M.
Jelic, V.
Almkvist, O.
Collette, Fabienne ; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie
Blacker D, Albert MS, Bassett SS, Go RC, Harrell LE, Folstein MF: Reliability and validity of NINCDS-ADRDA criteria for Alzheimer's disease: The National Institute of Mental Health Genetics Initiative. Arch Neurol 1994;51: 1198-1204.
Erkinjuntti T, Ostbye T, Steenhuis R, Hachinski V: The effect of different diagnostic criteria on the prevalence of dementia. N Engl J Med 1997;337:1667-1674.
Morris JC, Heyman A, Mohs RC, Hughes JP, van Belle G, Fillenbaum G, Mellits ED, Clark C: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). I. Clinical and neuropsychological assessment of Alzheimer's disease. Neurology 1989;39:1159-1165.
Neri M, Roth M, Mountjoy CQ, Andermarcher E, Rubichi S, Spano A, Salvioli G, Cipolli C: Validation of the full and short forms of the CAMDEX interview for diagnosing dementia: Cambridge Examination for Mental Disorders of the Elderly. Dementia 1994;5:257-265.
Doraiswamy PM, Bieber F, Kaiser L, Krishnan KR, Reuningscherer J, Gulanski B: The Alzheimer's disease assessment scale - Patterns and predictors of baseline cognitive performance in multicenter Alzheimer's disease trials. Neurology 1997;48:1511-1517.
Petersen RC, Smith GE, Ivnik RJ, Tangalos EG, Schaid DJ, Thibodeau SN, Kokmen E, Waring SC, Kurland LT: Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals. JAMA 1995;273:1274-1278.
Lendon CL, Ashall F, Goate AM: Exploring the etiology of Alzheimer disease using molecular genetics. JAMA 1997;277:825-831.
Jobst KA, Barnetson LP, Shepstone BJ: Accurate prediction of histologically confirmed Alzheimer's disease and the differential diagnosis of dementia: The use of NINCDS-ADRDA and DSM-III-R criteria, SPECT, X-ray CT, and APO E4 medial temporal lobe dementias: The Oxford Project to Investigate Memory and Aging. Int Psychogeriatr 1997;9(suppl 1):191-222, discussion 247-252.
Stern Y, Tang MK, Albert MS, Brandt J, Jacobs DM, Bell K, Marder K, Sano M, Devanand D, Albert SM, Bylsma F, Tsai WY: Predicting time to nursing home care and death in individuals with Alzheimer disease. JAMA 1997;277:806-812.
Devanand DP, Folz M, Gorlyn M, Moeller JR, Stern Y: Questionable dementia: Clinical course and predictors of outcome. J Am Geriatr Soc 1997;45:321-328.
Rapoport SI: Positron emission tomography in Alzheimer's disease in relation to disease pathogenesis - A critical review. Cerebrovasc Brain Metab Rev 1991;3:297-335.
Jagust WJ: Functional imaging patterns in Alzheimer's disease: Relationships to neurobiology. Ann NY Acad Sci 1996;777:30-36.
Grady CL, Haxby JV, Horowitz B, Sundaram M, Berg G, Schapiro M, Friedland RP, Rapoport SI: Longitudinal study of the early neuropsychological and cerebral metabolic changes in dementia of the Alzheimer type. J Clin Exp Neuropsychol 1988;10:576-596.
Reiman EM, Caselli RJ, Yun LS, Chen K, Bandy D, Minoshima S, Thibodeau SN, Osborne D: Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J Med 1996;334: 752-758.
Minoshima S, Giordani B, Berent S, Frey KA, Foster NL, Kuhl DE: Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease. Ann Neurol 1997;42:85-94.
Herholz K, Adams R, Kessler J, Szelies B, Grond M, Heiss WD: Criteria for the diagnosis of Alzheimer's disease with positron emission tomography. Dementia 1990;1:156-164.
Herholz K, Perani D, Salmon E, Franck G, Fazio F, Heiss WD, Comar D: Comparability of FDG PET studies in probable Alzheimer's disease. J Nucl Med 1993;34:1460-1466.
Folstein MF, Folstein SE, McHugh PR: 'Mini-mental state': A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
Ruff RM, Light RH, Quayhagen M: Selective reminding tests: A normative study of verbal learning in adults. J Clin Exp Neuropsychol 1988;11:539-550.
Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL: A new clinical scale for the staging of dementia. Br J Psychiatry 1982;140:566-572.
Reisberg B, Ferris SH, DeLeon MJ, Crook T: The global deterioration scale for assessment of primary degenerative dementia. Am J Psychiatry 1982;139:1136-1139.
Reivich M, Kuhl D, Wolf A, Greenberg J, Phelps M, Ido T, Casella V, Fowler J, Hoffman E, Alavi A, Som P, Sokoloff L: The [18F]flourodeoxyglucose method for the measurement of local cerebral glucose utilization in man. Circ Res 1979;44:127-137.
Phelps ME, Huang SC, Hoffman EJ, Selin C, Sokoloff L, Kuhl DE: Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: Validation of method. Ann Neurol 1979; 6:371-388.
Kumar A, Schapiro MB, Grady C, Haxby JV, Wagner E, Salerno JA, Friedland RP, Rapoport SI: High-resolution PET studies in Alzheimer's disease. Neuropsychopharmacology 1991;4:35-46.
Mielke R, Herholz K, Grond M, Kessler J, Heiss WD: Clinical deterioration in probable Alzheimer's disease correlates with progressive metabolic impairment of association areas. Dementia 1994;5:36-41.
Herholz K: FDG PET and differential diagnosis of dementia. Alzheimer Dis Assoc Disord 1995;9:6-16.
Haxby JV, Grady CL, Duara R, Schlageter N, Test T, Rapoport SI: Neocortical metabolic abnormalities precede nonmemory cognitive defects in early Alzheimer's-type dementia. Arch Neurol 1986;43:882-885.
Azari NP, Pettigrew KD, Schapiro MB, Haxby JV, Grady CL, Pietrini P, Salerno JA, Heston L, Rapoport SI, Horwitz B: Early detection of Alzheimer's disease: A statistical approach using positron emission tomographic data. J Cereb Blood Flow Metab 1993;13:438-447.
Kennedy AM, Frackowiak RS, Newman SK, Bloomfield PM, Seaward J, Roques P, Lewington G, Cunningham VJ, Rossor MN: Deficits in cerebral glucose metabolism demonstrated by positron emission tomography in individuals at risk of familial Alzheimer's disease. Neurosci Lett 1995;186:17-20.
Small GW, Mazziotta JC, Collins MT, Baxter LR, Phelps ME, Mandelkern MA, Kaplan A, La Rue A, Adamson CF, Chang L, et al: Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease. JAMA 1995;273:942-947.
Heiss WD, Pawlik G, Holthoff V, Kessler J, Szelies B: PET correlates of normal and impaired memory functions (review). Cerebrovasc Brain Metab Rev 1992;4:1-27.
Perani D, Bressi S, Cappa SF, Vallar G, Alberoni M, Grassi F, Caltagirone C, Cipolotti L, Franceschi M, Lenzi GL, et al: Evidence of multiple memory systems in the human brain: A [18F]FDG PET metabolic study. Brain 1993; 116:903-919.
Lucchelli F, De Renzi E, Perani D, Fazio F: Primary amnesia of insidious onset with subsequent stabilisation. J Neurol Neurosurg Psychiatry 1994;57:1366-1370.
Miceli G, Colosimo C, Daniele A, Marra C, Perani D, Fazio F: Isolated amnesia with slow onset and stable course, without ensuing dementia: MRI and PET data and a six-year neuropsychological follow-up. Dementia 1996;7: 104-110.
Baxter LR Jr, Schwartz JM, Phelps ME, Mazziotta JC, Guze BH, Selin CE, Gerner RH, Sumida RM: Reduction of prefrontal cortex glucose metabolism common to three types of depression. Arch Gen Psychatry 1989;46:243-250.
Biver F, Goldman S, Delvenne V, Luxen A, De Maertelaer V, Hubain P, Mendlewicz J, Lotstra F: Frontal and parietal metabolic disturbances in unipolar depression. Biol Psychiatry 1994; 36:381-388.
Kumar A, Newberg A, Alavi A, Berlin J, Smith R, Reivich M: Regional cerebral glucose metabolism in late-life depression and Alzheimer disease: A preliminary positron emission tomography study. Proc Natl Acad Sci USA 1993;90:7019-7023.
Guze BH, Baxter LR Jr, Schwartz JM, Szuba MP, Maziotta JC, Phelps ME: Changes in glucose metabolism in dementia of the Alzheimer type compared with depression: A preliminary report. Psychiatry Res 1991;40:195-202.
Rapoport SI: Discriminant analysis of brain imaging data identifies subjects with early Alzheimer's disease. Int Psychogeriatr 1997;9 (suppl 1):229-235, discussion 247-252.
Mielke R, Herholz K, Grond M, Kessler J, Heiss WD: Severity of vascular dementia is related to volume of metabolically impaired tissue. Arch Neurol 1992;49:909-913.
Salmon E, Sadzot B, Maquet P, Degueldre C, Lemaire C, Rigo P, Comar D, Franck G: Differential diagnosis of Alzheimer's disease with PET. J Nucl Med 1994;35:391-398.
Kuhl DE, Metter EJ, Riege WH: Patterns of local cerebral glucose utilization determined in Parkinson's disease by the [18F]fluorodeoxyglucose method. Ann Neurol 1984;15:419-424.
Schapiro MB, Pietrini P, Grady CL, Ball MJ, DeCarli C, Kumar A, Kaye JA, Haxby JV: Reductions in parietal and temporal cerebral metabolic rates for glucose are not specific for Alzheimer's disease. Neurol Neurosurg Psychiatry 1993;56:859-864.
Albin RL, Minoshima S, D'Amato C, Frey KA, Kuhl DA, Sima AAF: Fluoro-deoxyglucose positron emission tomography in diffuse Lewy body disease. Neurology 1996;47:462-466.
Ishii K, Imamura T, Sasaki M, Yamaji S, Sakamoto S, Kitagaki H, Hashimoto M, Hirono N, Shimomura T, Mori E: Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease. Neurology 1998;51: 125-130.
Corder EH, Jelic V, Basun H, Lannfelt L, Valind S, Winblad B, Nordberg A: No difference in cerebral glucose metabolism in patients with Alzheimer disease and differing apolipoprotein E genotypes. Arch Neurol 1997;54:273-277.
Rossor MN, Kennedy AM, Frackowiak RS: Clinical and neuroimaging features of familial Alzheimer's disease. Ann NY Acad Sci 1996; 777:49-56
Perani D, Grassi F, Sorbi S, Nacmias B, Piacentini S, Piersanti P, Provinciali L, Amaducci L, Fazio F: PET study in subjects from two Italian FAD families with APP717 Val to Ileu mutation. Eur J Neurol 1997;4:214-220.
Neary D: Dementia of frontal lobe type. J Am Geriatr Soc 1990;38:71-72.
Brun A: Frontal lobe degeneration of non-Alzheimer type revisited. Dementia 1993;4:126-131.
Holman BL, Johnson KA, Gerada B, Carvalho PA, Satlin A: The scintigraphic appearance of Alzheimer's disease: A prospective study using technetium-99m-HMPAO SPECT. J Nucl Med 1992;33:181-185.
Mielke R, Pietrzyk U, Jacobs A, Fink GR, Ichimiya A, Kessler J, Herholz K, Heiss WD: HMPAO SPECT and FDG PET in Alzheimer's disease and vascular dementia: Comparison of perfusion and metabolic pattern. Eur J Nucl Med 1994;21:1052-1060.
Messa C, Perani D, Lucignani G, Zenorini A, Zito F, Rizzo G, Grassi F, Del Sole A, Franceschi M, Gilardi MC, et al: High-resolution technetium-99m-HMPAO SPECT in patients with probable Alzheimer's disease: Comparison with fluorine-18-FDG PET. J Nucl Med 1994; 35:210-216.
Parnetti L, Lowenthal DT, Presciutti O, Pelliccioli GP, Palumbo R, Gobbi G, Chiarini P, Palumbo B, Tarducci R, Senin U: 1H-MRS, MRI-based hippocampal volumetry, and 99mTc-HMPAO-SPECT in normal aging, age-associated memory impairment, and probable Alzheimer's disease. J Am Geriatr Soc 1996; 44:133-138.
Mielke R, Herholz K, Grond M, Kessler J, Heiss WD: Differences of regional cerebral glucose metabolism between presenile and senile dementia of Alzheimer type. Neurobiol Aging 1992;13:93-98.
Becker JT, Boller F, Lopez OL, Saxton J, McGonigle KL: The natural history of Alzheimer's disease: Description of study cohort and accuracy of diagnosis. Arch Neurol 1994; 51:585-594.
Minoshima S, Frey KA, Koeppe RA, Foster NL, Kuhl DE: A diagnostic approach in Alzheimer's disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET. J Nucl Med 1995;36:1238-1248.
