Impairment of neocortical metabolism predicts progression in Alzheimer's disease

Herholz, K.; Nordberg, A.; Salmon, Eric; Perani, D.; Kessler, J.; Mielke, R.; Halber, M.; Jelic, V.; Almkvist, O.; Collette, Fabienne; Alberoni, M.; Kennedy, A.; Hasselbalch, S.; Fazio, F.; Heiss, W.-D.

doi:10.1159/000017196

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Impairment of neocortical metabolism predicts progression in Alzheimer's disease

Herholz, K.; Nordberg, A.; Salmon, Eric et al.

1999 • In Dementia and Geriatric Cognitive Disorders, 10 (6), p. 494-504

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https://hdl.handle.net/2268/61938

DOI
10.1159/000017196

PubMed
10559566

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Keywords :

Ka-ALZHEIMER'S DISEASE; Ka-CEREBRAL GLUCOSE METABOLISM; Ka-EMISSION COMPUTED TOMOGRAPHY; Ka-MULTICENTER STUDY; Ka-PROSPECTIVE STUDY

Abstract :

[en] Studied prediction of progression rates of Alzheimer's disease (AD) in a prospective multicenter cohort study of 186 patients (mean age 63.2 yrs) with possible or probable AD, mostly with presenile onset. In a cross-sectional analysis at entry, impairment of glucose metabolism in temporoparietal or frontal association areas measured with positron emission tomography was significantly associated with dementia severity, clinical classification as possible vs probable AD, presence of multiple cognitive deficits and history of progression. A prospective longitudinal analysis showed a significant association between initial metabolic impairment and subsequent clinical deterioration. In patients with mild cognitive deficits at entry, the risk of deterioration was up to 4.7 times higher if the metabolism was severely impaired than with mild or absent metabolic impairment.

Disciplines :

Neurology
Neurosciences & behavior

Author, co-author :

Herholz, K.

Nordberg, A.

Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.

Perani, D.

Kessler, J.

Mielke, R.

Halber, M.

Jelic, V.

Almkvist, O.

Collette, Fabienne ; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie

More authors (5 more)

Language :

English

Title :

Impairment of neocortical metabolism predicts progression in Alzheimer's disease

Publication date :

1999

Journal title :

Dementia and Geriatric Cognitive Disorders

ISSN :

1420-8008

eISSN :

1421-9824

Publisher :

S. Karger

Volume :

Issue :

Pages :

494-504

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 11 June 2010

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