[en] Using the [18F]fluorodeoxyglucose method and positron emission tomography, we studied cerebral glucose utilization during sleep and wakefulness in 11 young normal subjects. Each of them was studied at least thrice: during wakefulness, slow wave sleep (SWS) and rapid eye movement sleep (REMS), at 1 week intervals. Four stage 3-4 SWS and 4 REMS fulfilled the steady state conditions of the model. The control population consisted of 9 normal age-matched subjects studied twice during wakefulness at, at least, 1 week intervals. Under these conditions, the average difference between the first and the second cerebral glucose metabolic rates (CMRGlu was: -7.91 +/- 15.46%, which does not differ significantly from zero (P = 0.13). During SWS, a significant decrease in CMRGlu was observed as compared to wakefulness (mean difference: -43.80 +/- 14.10%, P less than 0.01). All brain regions were equally affected but thalamic nuclei had significantly lower glucose utilization than the average cortex. During REMS, the CMRGlu were as high as during wakefulness (mean difference: 4.30 +/- 7.40%, P = 0.35). The metabolic pattern during REMS appeared more heterogeneous than at wake. An activation of left temporal and occipital areas is suggested. It is hypothetized that energy requirements for maintaining membrane polarity are reduced during SWS because of a decreased rate of synaptic events. During REMS, cerebral glucose utilization is similar to that of wakefulness, presumably because of reactivated neurotransmission and increased need for ion gradients maintenance.
Disciplines :
Neurology
Author, co-author :
Maquet, Pierre ; Université de Liège - ULiège > Centre de recherches du cyclotron
Dive, Dominique ; Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman
Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Sadzot, Bernard ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Franco, Gianni ; Université de Liège - ULiège > Département des sciences cliniques
Poirrier, Robert ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
von Frenckell, Rémy ; Université de Liège - ULiège > Unité de Psychiatrie Biologique et de Psychopharmacologie
Franck, Georges ; Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
Cerebral Glucose Utilization During Sleep-Wake Cycle in Man Determined by Positron Emission Tomography and [18f]2-Fluoro-2-Deoxy-D-Glucose Method
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Bibliography
Adam, Oswald (1983) Protein synthesis, bodily renewal and sleep-wake cycle. Clin. Sci. 65:561-567.
Agranoff, Frey (1984) A regional metabolic contrast method for the study of brain pathology. Ann. Neurol. , Suppl.; 15:S93-S97.
Anchors, Karnovsky (1975) Purification of cerebral glucose-6-phosphatase. An enzyme involved in sleep. J. Biol. Chem. 250:6408-6416.
Aserinsky, Kleitman (1953) Regularly occuring periods of eye motility and concommittant phenomena during sleep. Science 118:273-274.
Dement, Kleitman (1957) Cyclic variations in EEG sleep and their relation to eye movements body motility, and dreaming. Electroencephalogr. Clin. Neurophysiol. 9:673-690.
Franck (1972) Brain slices. The Structure and Function of Nervous Tissue , G.H. Bourne, Academic Press, New York; 417-465.
Franck, Salmon, Poirrier, Sadzot, Franco (1987) Etude du métabolisme glucidique cérébral régional chez l'homme, au cours de l'éveil et du sommeil, par tomographie à émission de positrons. Rev. EEG Neurophysiol. Clin. 17:71-77.
Giuditta, Rutigliano, Vitale-Neugebauer (1980) Influence of synchronized sleep on the biosynthesis of RNA in two nuclear classes isolated from rabbit cerebral cortex. J. Neurochem. 35:1259-1266.
Giuditta, Rutigliano, Vitale-Neugebauer (1980) Influence of synchronized sleep on the biosynthesis of RNA in neuronal and mixed fractions isolated from rabbit cerebral cortex. J. Neurochem. 35:1267-1272.
Heiss, Pawlik, Herholz, Wagner, Wienhard (1985) Regional cerebral glucose metabolism in man during wakefulness, sleep, and dreaming. Brain Research 237:362-366.
Horne (1983) Human sleep and tissue restitution: some qualifications and doubts. Clin. Sci. 65:569-578.
Horne (1985) Sleep function, with particular reference to sleep deprivation. Ann. Clin. Res. 17:199-208.
Horne Why We Sleep , Oxford University Press, Oxford; 1988, 319.
Huang, Phelps, Hoffman, Sideris, Selin, Kuhl (1980) Noninvasive determination of local cerebral metabolic rate of glucose in man. Am. J. Physiol. 238:E69-E82.
Huang, Phelps, Hoffman, Kuhl (1981) Error sensitivity of fluorodeoxyglucose method for the measurement of cerebral metabolic rate of glucose. J. Cereb. Blood Flow Metab. 1:391-401.
Jouvet (1972) The role of monoamines and acetylcholine-containing neurons in the regulation of sleep-waking cycle. Ergeb. Physiol. 64:166-307.
Jouvet, Michel (1959) Corrélations électromyographiques du sommeil chez le chat décortiqué et mésencéphalique chronique. C.R. Soc. Biol. 153:422-425.
Kelly, McCulloch (1982) Effects of the putative GABAergic agonists, muscimol and THIP, upon local cerebral glucose utilisation. J. Neurochem. 39:613-624.
Kennedy, Gillin, Mendelson, Suda, Miyaoka, Ito, Nakamura, Storch, Pettigrew, Mishkin, Sokoloff (1982) Local cerebral glucose utilization in non-rapid eye movement sleep. Nature (Lond.) 297:325-327.
Krebs, Eggleston, Terner (1951) In vitro measurements of the turnover rate of potassium in brain and retina. Biochem. J. 48:530-537.
Livingstone, Hubel (1981) Effects of sleep and arousal on the processing of visual information in the cat. Nature (Lond.) 291:554-561.
Lowry (1975) Energy metabolism in brain and its control. Brain Work. The Coupling of Function, Metabolism and Blood Flow in the Brain. A. Benzon Symposium VIII , D.H. Ingvar, N.A. Lassen, Munksgaard, Copenhagen; 48-64.
Mangold, Sokoloff, Conner, Kleinerman, Therman, Kety (1955) The effects of sleep and lack of sleep on the cerebral circulation and metabolism of normal young men. J. Clin. Invest. 34:1092-1100.
Mata, Fink, Gainer, Smith, Davidsen, Savaki, Schwartz, Sokoloff (1980) Activity-dependent energy metabolism in rat posterior pituitary primarily reflects sodium pump activity. J. Neurochem. 34:213-215.
Mazziotta, Phelps, Miller, Kuhl (1981) Tomographic mapping of human cerebral metabolism: normal unstimulated state. Neurology 31:503-516.
Mazziotta, Phelps, Carson, Kuhl (1982) Tomographic mapping of human cerebral metabolism: auditory stimulation. Neurology 32:921-937.
Nakamura, Kennedy, Gillin, Suda, Ito, Storch, Mendelson, Sokoloff, Mishkin (1983) Hypnogenic center theory of sleep: no support from metabolic mapping in monkeys. Brain Research 268:372-376.
Petitjean, Seguin, Des Rosiers, Salvert, Buda, Janin, Debilly, Jouvet, Bobillier (1981) Consommation cérébrale locale de glucose au cours de l'éveil et du sommeil lent chez le chat. C.R. Acad. Sci. 292:1211-1214.
Phelps, Huang, Hoffman, Selin, Sokoloff, Kuhl (1979) Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)-2-fluro-2-deoxy-d-glucose: validation of method. Ann. Neurol. 6:371-388.
Phelps, Mazziotta, Kuhl, Nuwer, Packwood, Metter, Engel (1981) Tomographic mapping of cerebral metabolism: visual stimulation and deprivation. Neurology 31:517-529.
Phelps, Mazziotta, Huang (1982) Study of cerebral function with positron computed tomography. J. Cereb. Blood Flow Metab. 2:113-162.
Ramm, Frost (1983) Regional metabolic activity in the rat brain during sleep-wake activity. Sleep 6:196-216.
Ramm, Frost (1986) Cerebral and local cerebral metabolism in the cat during slow wave and REM sleep. Brain Research 365:112-124.
Ramm, Smith (1987) Cerebral protein synthesis during slow wave and REM sleep in the rat. Proceedings of the 5th International Congress on Sleep Research , Copenhagen; 45.
Rechtschaffen, Kales A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects, 3rd edn., U.S. Department of Health, Education and Welfare, Bethesda, MD; 1968.
Reich, Driver, Karnovsky (1967) Sleep: effects on incorporation of inorganic phosphate into brain fractions. Science 157:336-338.
Reich, Geyer, Karnovsky (1972) Metabolism of brain during sleep and wakefulness. J. Neurochem. 19:487-497.
Reich, Geyer, Steinbaum, Anchors, Karnovsky (1973) Incorporation of phosphate into rat brain during sleep and wakefulness. J. Neurochem. 20:1195-1205.
Richter, Dawson (1948) Brain metabolism in emotional excitement and in sleep. Am J Physiol 154:73-79.
Salamon, Huang Computed Tomography of the Brain , Springer, Berlin; 1980, 155.
Snapiro (1982) Energy expenditure and restorative sleep. Biol. Psychol. 15:229-239.
Shimizu, Tabushi, Hishikawa, Kakimoto, Kaneko (1966) Concentrations of lactic acid in rat brain during natural sleep. Nature (Lond.) 212:936-937.
Smith (1985) Sleep states and learning: a review of animal literature. Neurosci. Biobehav. Rev. 9:157-168.
Sokoloff (1977) Relation between physiological function and energy metabolism in the central nervous system. J. Neurochem. 29:13-26.
Sokoloff, Reivich, Kennedy, Des Rosiers, Patlak, Pettigrew, Sakurada, Shinohara (1977) The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure and normal values in the conscious and anesthetized albino rat. J. Neurochem. 28:897-916.
Steriade, Hobson (1976) Neuronal activity during the sleep-waking cycle. Prog. Neurobiol. 6:155-376.
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