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Neuronotrophic Effect of Developing Otic Vesicle on Cochleo-Vestibular Neurons: Evidence for Nerve Growth Factor Involvement
Lefebvre, Philippe; Leprince, Pierre; Weber, T. et al.
1990In Brain Research, 507 (2), p. 254-60
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Abstract :
[en] In the developing inner ear, the existence of a neuronal death and of a peripheral target-derived trophic effect on cochleovestibular neurons has been documented. Using cultures of rat cochleovestibular neurons, we show that the E12 otic vesicle releases a factor promoting the survival and the neuritogenesis of these neurons, and that this effect is mimicked by NGF. The effect of the optic vesicle conditioned medium (OVCM) on cochleovestibular neurons is suppressed by anti-NGF antibodies. OVCM is neuronotrophic for NGF-sensitive sympathetic neurons, an effect that is also suppressed by anti-NGF antibodies, further demonstrating the presence of biologically active nerve growth factor.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Lefebvre, Philippe ;  Université de Liège - ULiège > O.R.L.
Leprince, Pierre ;  Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc.
Weber, T.
Rigo, Jean-Michel
Delree, P.
Moonen, Gustave  ;  Université de Liège - ULiège > Neurologie Sart Tilman
Language :
English
Title :
Neuronotrophic Effect of Developing Otic Vesicle on Cochleo-Vestibular Neurons: Evidence for Nerve Growth Factor Involvement
Publication date :
22 January 1990
Journal title :
Brain Research
ISSN :
0006-8993
eISSN :
1872-6240
Publisher :
Elsevier, Netherlands
Volume :
507
Issue :
2
Pages :
254-60
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 01 June 2010

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