[en] Varicella zoster virus (VZV) is recognized as one of the major viral pathogens reactivated in patients with the acquired immune deficiency syndrome (AIDS). We report the case of meningoradiculoneuritis in an AIDS patient, associated with the isolation in the cerebrospinal fluid (CSF) of a thymidine kinase (TK)-deficient, acyclovir (ACV)-resistant strain of VZV. Although the virus was sensitive in vitro to phosphonoformate (PFA), the patient did not improve during PFA therapy and finally died. Several VZV strains isolated from this patient (including two isolates from the patient's CSF) were analyzed for their TK activity and subsequently the viral TK gene was sequenced showing a major deletion leading to a truncated protein. Their susceptibility to several antiviral agents including ACV, PFA, (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), 9-beta-D-arabinofuranosyladenine (vidarabine), (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine (HPMPC), and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) was evaluated. All the virus strains isolated from this patient remained sensitive to HPMPA and HPMPC, pointing to the potential usefulness of these acyclic nucleoside phosphonates for the treatment of ACV-resistant VZV infections in immunocompromised patients. (C) 1994 Wiley-Liss, Inc.
Disciplines :
Immunology & infectious disease
Author, co-author :
Snoeck, R.; Katholieke Universiteit Leuven - KUL
Gérard, M.; Hôpital Saint-Pierre (Bruxelles)
Sadzot-Delvaux, Catherine ; Université de Liège - ULiège > Département des sciences de la vie > Virologie et immunologie
Andrei, G.; Katholieke Universiteit Leuven - KUL
Balzarini, J.; Katholieke Universiteit Leuven - KUL
Reymen, D.; Katholieke Universiteit Leuven - KUL
Ahadi, N.; Hôpital Saint-Pierre (Bruxelles)
Debruyn, J. M.; Institut Bordet
Piette, Jacques ; Université de Liège - ULiège > Département des sciences de la vie > Virologie - Immunologie
Rentier, Bernard ; Université de Liège - ULiège > Département de Microbiologie > Virologie fondamentale et Immunologie
Clumeck, N.; Hôpital Saint-Pierre (Bruxelles)
De Clercq, E.; Katholieke Universiteit Leuven - KUL
Language :
English
Title :
Meningoradiculoneuritis due to acyclovir-resistant varicella zoster virus in an acquired immune deficiency syndrome patient
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