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Article (Scientific journals)
Oxidant-Scavenging Activities of Beta-Lactam Agents
Carreer, R.; Deby-Dupont, G.; Deby, C. et al.
1998In European Journal of Clinical Microbiology and Infectious Diseases, 17 (1), p. 43-6
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Keywords :
antibiotics; recative oxygene species; antioxidant
Abstract :
[en] The relative antioxidant effect of ampicillin, ceftazidime, ceftriaxone, and cefuroxime on oxygen-reactive species was examined in vitro using stimulated human polymorphonuclear neutrophils. There was no evidence that any of the beta-lactam agents tested had an effect on superoxide or H2O2 generation. In contrast, all of the beta-lactam agents prevented hypochlorous acid (HOCI) chlorination of 1,1-dimethyl-4-chloro-3,5-cyclo-hexanedione in a cell-free system at concentrations of < 10 microg/ml. Furthermore, all antibiotics provided dose-dependent protection against HOCI cytotoxicity to 16HBE140 bronchial epithelial cells. Taken together, these data indicate a possible therapeutic role for beta-lactam agents in protecting host tissues from HOCI-induced oxidative damage.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Carreer, R.;  Eurogentec
Deby-Dupont, G.;  Université de Liège - ULiège > Centre Interdisciplinaire de Biochimie de l'Oxygène
Deby, C.;  Université de Liège - ULiège > Centre Interdisciplinaire de Biochimie de l'Oxygène
Jadoul, L.;  Glaxo Welcome
Mathy, Marianne ;  Université de Liège - ULiège > Centre Interdisciplinaire de Biochimie de l'Oxygène
Language :
English
Title :
Oxidant-Scavenging Activities of Beta-Lactam Agents
Publication date :
January 1998
Journal title :
European Journal of Clinical Microbiology and Infectious Diseases
ISSN :
0934-9723
eISSN :
1435-4373
Publisher :
Springer, Germany
Volume :
17
Issue :
1
Pages :
43-6
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 February 2010

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