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Article (Scientific journals)
Mitogen-activated lymphocytes: a good model for characterising lung CYP1A1 inducibility
Jacquet, Michèle; LAMBERT, Vincent; Todaro, Anne et al.
1997In European Journal of Epidemiology, 13 (2), p. 177-183
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Keywords :
CYP1A1; Lung cancer; Lymphocyte
Abstract :
[en] The CYP1A1 hyperinducibility phenotype occurring in some 10% of the human population corresponds to a higher risk of developing lung cancer. This study was undertaken to assess whether the inducibility factor, generally evaluated on mito- gen-activated lymphocytes after PAH induction, represents correctly the lung situation. Optimal experimental conditions were determined for evalu- ating, on both lymphocytes and lung tissue explants, the inducibility factor, defined as the ratio of EROD activity (CYP1A1-specific) to cytochrome c reduc- tase activity (unaffected by PAH induction). Paired results for lymphocytes and lung tissue samples from 10 lung cancer patients were compared. A good correlation was observed between lymphocyte and lung tissue inducibilities (R = 0.809; p = 0.005). In conclusion, mitogen-activated lymphocyte induci- bility is indicative of lung tissue inducibility and constitutes a good marker for evaluating individual PAH inducibilities.
Disciplines :
General & internal medicine
Oncology
Author, co-author :
Jacquet, Michèle;  Centre Hospitalier Universitaire de Liège - CHU > Service de Chimie Médicale
LAMBERT, Vincent  ;  Centre Hospitalier Universitaire de Liège - CHU > Ophtalmologie
Todaro, Anne;  Centre Hospitalier Universitaire de Liège - CHU > Service Chimie Medicale
Kremers, Pierre;  Centre Hospitalier Universitaire de Liège - CHU > Service Chimie Medicale
Language :
English
Title :
Mitogen-activated lymphocytes: a good model for characterising lung CYP1A1 inducibility
Publication date :
February 1997
Journal title :
European Journal of Epidemiology
ISSN :
0393-2990
eISSN :
1573-7284
Publisher :
Kluwer Academic Publishers, Dordrecht, Netherlands
Volume :
13
Issue :
2
Pages :
177-183
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 October 2015

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