Reference : Growth Factor Interactions in Cultures of Dissociated Adult Acoustic Ganglia: Neurono...
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/36089
Growth Factor Interactions in Cultures of Dissociated Adult Acoustic Ganglia: Neuronotrophic Effects
English
LEFEBVRE, Philippe mailto [> > > >]
Van de Water, T. R. [> > > >]
Weber, T. [> > > >]
Rogister, Bernard mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Moonen, Gustave mailto [Université de Liège - ULiège > Département des sciences cliniques > Neurologie - Doyen de la Faculté de Médecine]
20-Dec-1991
Brain Research
567
2
306-12
Yes (verified by ORBi)
International
0006-8993
1872-6240
[en] Auditory neurons cultured from adult rat acoustic ganglia require for survival either a substrate bound factor(s) present in astrocyte conditioned medium or substrate bound basic fibroblast growth factor (bFGF). Nerve growth factor (NGF) is not a survival factor for these neurons in vitro, but when used in combination with substrate bound bFGF, NGF does vigorously stimulate a neuritogenesis response by these neurons. Transforming growth factor beta (TGF beta 1) enhances the survival effect that bFGF has on these adult auditory neurons but does not by itself promote their survival in dissociated acoustic ganglion cultures. We propose that there may be complex interactions and synergy exerted by these growth factors (i.e. bFGF, NGF, TGF beta 1) during injury to the inner ear.
http://hdl.handle.net/2268/36089
10.1016/0006-8993(91)90809-A

There is no file associated with this reference.

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.