[en] We summarize the anatomical and physiological basis and the ways of measuring the intestinal permeability. We review the studies of the intestinal permeability in Crohn's disease. We analyse the involvement of an abnormal intestinal permeability in the pathogenesis of Crohn's disease, as a primary or secondary defect. We discuss the potential usefulness of the measure of intestinal permeability in Crohn's disease activity assessment, relapse prediction and efficacy of treatment.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Franchimont, D.
Louis, Edouard ; Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie
Simon, Sarah ; Centre Hospitalier Universitaire de Liège - CHU > Hématologie biologique et immuno hématologie
Belaiche, Jacques ; Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie
LEVINE J. Exogenous factors in Crohn's disease. A critical review. J. Clin. Gastroenterol., 1992,14(3) 216-26.
CRISSINGER K.D., KVIETY P.R., GRANGER D.N. Pathophysiology of gastrointestinal mucosal permeability J. Intern Med, 1990, 228, Suppl I : 145-154.
SANDERSON I.R., WALKER W.A. Uptake and Transport of macromolecules by the intestine : Possible role in clinical disorders (an update). Gastroenterology, 1993, 104 . 622-639.
NAFTALIN R.J , TRIPATHI S. Passive water flows driven across the isolated rabbit ileum by osmotic, hydrostatic and electrical gradients. J. Physiol., 1985, 360 . 27-50.
FORDTRAN J.S., RECTOR E.C., EWTON M.F., SOTER N., KINNEY J Permeability characteristics of the human small intestine J. Clin. Invest, 1965, 44 : 1935-44
LINDEMAN B., SOLOMOX A.K. Permeability of luminal surface of intestinal mucosal cells. J. Gen Physiol., 1962, 45 : 80-810
MADARA J.L., PARKOS C., COLGAN S., NURSAT A., ATISOOK K., KAOUTZANI P. The movement of solutes and cells across tight junctions. Neuro-immuno-physiology of the gastrointestinal mucosa. Ann. NY Acad. Sci., 664 47-60.
BRANDZAEG P. Research in gastrointestinal Immunology. State of the Art Scand. J Gastroenterol., 20, suppl 114 : 137-156.
BRANDZAEG P., HALSTENSEN T S , KETT K., KRAJCI P., KVALE D., ROGNUM T.O, SCOTT H., SOLLID L.M. Immunobiology and Immunopathology of human gut mucosa: Humoral immunity and Itraepithelial Lymphocytes. Gastroenterology, 1989, 97 : 1562-84.
ELSON C.O. Induction and Control of the Gastrointestinal Immune System. Scand. J., Gastroentrol., 20, suppl 114 : 1-15.
BJARNAZON I., MACPHERSON A., HOLLANDER D. Intestinal permeability : an overview. Gastroenterology, 1995, 108 : 1566-1581.
HERESBACH D , LE GALL R., BRETAGNE J.F., GOSSELIN M. Etude de la permeabilité intestinale chez l'homme. Gastroenterol. clin. Biol. 1994, 18 . 638-648.
TRAVIS S., MENZIES I. Intestinal permeability : functional assessment and significance. Clin Sci., 1992, 82 : 471-488.
OLAISON G , SJODAHL R., TAGESSON C. Abnormal intestinal permeability in Crohn's disease. A possible pathogenic factor. Scand. J. Gastroenterol., 1990, 25: 321-328.
HOLLANDER D., RICKETTS D , BOYD Car. The importance of 'probe' molecular geometry in determining intestinal permeability. Scan. J. Gastroenterol. 1988, 2 . 35a-38a.
MARCIAL Ma , CARLSON SI., MADARA JI. Partitioning of paracellular conductance along the ileal and crypt-villus axis : a hypothesis based on structural analysis with detailed consideration of tight junction structure-function relationships. J. Membrane Biol. 1984, 80 : 59-70.
HOLLANDER D. Crohn's disease - a permeability disorder of the tight junction? Gut , 1988, 29 : 1621-1624
HOLLANDER D The intestinal permeability barrier. A hypothesis as to its regulation and involvement in Crohn's Disease. Review - Scand. J. Gastroenterol., 1992, 27 . 721-726.
OLAISON G., SHIDAGK R., LEANDERSSON P., TAGESSON C. Abnormal intestinal permeability pattern in colonic Crohn's disease. Absorption of low molecular weight polyethylene glycols after oral or colonic load. Scand. J. Gastroentérol., 1989, 24 : 571-76.
HOWDEN C.W., GILLANDERS I., MORRIS A.J., DUCA A., DANESH B., RUSSELL R I. Intestinal permeability in patients with Crohn's disease and their first degree relatives. Am. J. Gastroenterol., 1994, 89 : 1175-1176
UKABAM S.O., COOPER B.T. Small intestinal permeability to mannitol, lactulose and poly-ethylene glycol 400 in coeliac disease. Dig. Dis Sci., 1984, 29 : 809-816.
HOLLANDER D., VADHEIM C.M., BRETTHOLZ E., PETERSEN G.M , DELAHUNTY T.J., ROTTER J.I. Increased intestinal permeability in patients with Crohn's disease and their relatives. Ann. Intern. Med., 1986, 105 : 883-5.
RUITENHERG D., YOUNG G.O., WRIGHT J.P., ISAACS S. PEG-400 Excretion in patients with Crohn's disease, their first-degree relatives and healthy volunteers. Dig. Dis. Sci., 1992, 37 : 705-708.
AINSWORTH M., ERIKSEN J., WAEVER RASMUSSEN J., SCHAFFALLITZKY DE MUCKADELL O.B. Intestinal permeability of Crlabelled ethylenediaminetetraacetic acid in patients with Crohn's disease and their healthy relatives Scand. J. Gastroenterol., 1989, 24 : 993-998.
K D KATZ, D. HOLLANDER, C M. VADHEIM, C. MC ELREE, T. DELAHUNTY, V.D. DADUFALZA, P. KRUGLIAK, J.I. ROTTER Intestinal permeability in patients with Crohn's disease and their healthy relatives. Gastroenterology. 1989, 97 : 927-931.
TEAHON K , SMETHURST P., LEVI A J., MENZIES I.S., BJARNASON I. Intestinal permeability in patients with Crohn's disease and their first degree relatives. Gut, 1992, 33 : 320-323.
MAY G.R., SUTHERLAND L.R. Is small intestinal permeability really increased in relatives of patients with Crohn's disease ? Meddings. Gastroenterology, 1993, 104 : 1627-1632.
PEETERS M. et al. Increased permeability of macroscopically normal small bowel in Crohn's disease. Dig Dis Sci. 1994, 39 : 2170-2176
HOLLANDER D Permeability in Crohn's disease, altered barrier functions in healthy relatives? Gastroenterology, 1993, 104 . 1848-1854.
WYATT J., VOGELSANG H., HUBL W., WALDHOER T., LOCHS H. Intestinal permeability and the prediction of relapse in Crohn's disease. Lancet. 1993, 341 . 1437-1439.
BJARNASON I Intestinal permeability. Gut, 1994, supplement I. S18-S22
SANDERSON I R , BOULTON P., MENZIES I.S., WALKER-SMITH J.A. Improvement of abnormal Lactutose, rhamnose permeability in active Crohn's disease of the small bowel by the elemental diet. Gut, 1987, 28 : 1073-76.
TEAHON K , SMETHURST P., LEVI A.J., BJARNASON I. The effect of the elemental diet on intestinal permeability and inflammation in Crohn's disease. Gastroenterology, 1991, 101 : 84-89
