Reference : Role de l' alpha 1-glycoproteine acide plasmatique dans la fixation de l'aminopyrine.
Scientific journals : Article
Human health sciences : Laboratory medicine & medical technology
Role de l' alpha 1-glycoproteine acide plasmatique dans la fixation de l'aminopyrine.
[en] The role of plasma alpha 1-glycoprotein acid in the binding of aminopyrine
El Allaf, Dia [Centre Hospitalier Universitaire de Liège - CHU > > Cardiologie >]
Demey-Ponsart, E. [> > > >]
Pirotte, J. [> > > >]
Chapelle, Jean-Paul mailto [Université de Liège - ULiège > Département de pharmacie > Chimie médicale >]
el Allaf, M. [> > > >]
Carlier, J. [> > > >]
Van Cauwenberge, Henry [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie appareil locomoteur >]
Archives Internationales de Physiologie et de Biochimie
Vaillant Carmanne
Yes (verified by ORBi)
[en] Aminopyrine/blood ; Binding Sites ; Humans ; Myocardial Infarction/blood ; Orosomucoid/blood ; Protein Binding
[en] Under certain pathological conditions the binding of various substances by serum proteins is altered. The plasma concentrations of alpha 1-acid glycoprotein, also known as orosomucoid are reported to be elevated in stressful situation and in certain disease states like acute myocardial infarction. The binding of aminopyrine to serum proteins and alpha 1-acid glycoprotein was determined using equilibrium dialysis. It appears that alpha 1-acid glycoprotein has specific binding sites for aminopyrine. Aminopyrine was also bound to other serum proteins. On addition the results indicate that an increase of alpha 1-acid glycoprotein to concentrations such as those seen in some pathological states does not really alter the percent of aminopyrine bind to serum proteins.

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