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Article (Scientific journals)
Changes in cerebrospinal fluid enzyme activity after severe head injury. Diagnostic and prognostic values.
Hans, Pol; Born, J. D.; Chapelle, Jean-Paul et al.
1984In Acta Anaesthesiologica Belgica, 35 (1), p. 79-86
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Keywords :
Adolescent; Adult; Child; Child, Preschool; Coma/cerebrospinal fluid; Craniocerebral Trauma/cerebrospinal fluid; Creatine Kinase/cerebrospinal fluid; Female; Humans; Isoenzymes; L-Lactate Dehydrogenase/cerebrospinal fluid; Male; Middle Aged; Prognosis
Abstract :
[en] We studied CSF CK and LDH isoenzyme activities in 27 patients with severe head injury and in 10 patients with chronic hydrocephalus not related to trauma. CSF enzymes showed an increased activity immediately after trauma, contrasting with the low values measured in the patients with hydrocephalus. In severe head injury, we found a correlation between enzyme release and brain dysfunction assessed according to two methods: the Glasgow coma scale (GCS), and the Liege coma scale (LCS) which uses elements of the GCS and the study of 5 brain stem reflexes. The correlation between enzyme activity and the Liege coma scores is better than that observed with the Glasgow coma scores. High enzyme activity is associated with a bad outcome at six months. It has a prognostic value on so far as it reflects the severity of traumatic structural brain damage.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
Hans, Pol ;  Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
Born, J. D.
Chapelle, Jean-Paul ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Spyropoulos, E.
Bodson, Lucien ;  Centre Hospitalier Universitaire de Liège - CHU > Urgences
Language :
English
Title :
Changes in cerebrospinal fluid enzyme activity after severe head injury. Diagnostic and prognostic values.
Publication date :
1984
Journal title :
Acta Anaesthesiologica Belgica
ISSN :
0001-5164
eISSN :
2736-5239
Publisher :
Acta Medica Belgica, Bruxelles, Belgium
Volume :
35
Issue :
1
Pages :
79-86
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 February 2010

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