Reference : Factors influencing between-laboratory variability of C-reactive protein results as e...
Scientific journals : Article
Human health sciences : General & internal medicine
Human health sciences : Laboratory medicine & medical technology
Factors influencing between-laboratory variability of C-reactive protein results as evidenced by the Belgian External Quality Assessement (EQA) Scheme
Devleeschouwer, N. [> >]
Libeer, J. C. [> >]
Chapelle, Jean-Paul mailto [Université de Liège - ULiège > Département de pharmacie > Chimie médicale >]
Struway, C. L. [> >]
Gyssels, C. [> >]
L'Hoir, A. [> >]
Albert, Adelin mailto [Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique]
Scandinavian Journal of Clinical and Laboratory Investigation
Taylor & Francis Health Sciences
Yes (verified by ORBi)
[en] Belgium ; C-Reactive Protein/analysis ; Calibration ; Fluorescence Polarization Immunoassay ; Humans ; Immunodiffusion ; Laboratories/standards ; Nephelometry and Turbidimetry ; Quality Control ; Reproducibility of Results
[en] Based on results from the Belgian External Quality Assessment (EQA) Scheme, we studied the main factors affecting the between-laboratory variation of C-reactive protein determination. Participants using homogeneous systems with several calibration points generally achieved better performance. Working temperatures influenced the results to a lesser extent. The present study stresses the importance for EQA organizers to collect more detailed information about CRP analytical methods used by the participants. It also suggests that manufacturers should be more involved in the management of quality, in particular by striving for standardization of the material (kit and calibrator) they produce for CRP assay.

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