Reference : Derivation of a bioclinical prognostic index in severe head injury.
Scientific journals : Article
Human health sciences : Laboratory medicine & medical technology
Derivation of a bioclinical prognostic index in severe head injury.
Hans, Pol [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Albert, Adelin mailto [Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique - Département de mathématique >]
Born, J. D. [> > > >]
Chapelle, Jean-Paul mailto [Université de Liège - ULiège > Département de pharmacie > Chimie médicale >]
Intensive Care Medicine
Springer Verlag
Yes (verified by ORBi)
New York
[en] Adolescent ; Adult ; Age Factors ; Child ; Child, Preschool ; Craniocerebral Trauma/diagnosis/mortality ; Creatine Kinase/cerebrospinal fluid ; Female ; Humans ; Intracranial Pressure ; Isoenzymes ; Male ; Middle Aged ; Prognosis ; Risk ; Statistics as Topic
[en] We investigated the problem of outcome prediction from seven risk factors in 40 severely head injured patients - 13 favorable and 27 unfavorable outcomes. By applying stepwise logistic discriminant analysis to the patients' data, we selected three significant risk variables: cerebrospinal fluid (CSF) CK-BB isoenzyme activity recorded on admission, severely raised intracranial pressure (more than 40 mmHg) and age, respectively. CSF CK-BB activity, which quantifies the initial neurological damage, proved to be the best prognostic factor. The presence of severe intracranial hypertension was always associated with a bad outcome, whereas its absence was not necessarily indicative of good prognosis. Finally, we combined the three selected variables into a single risk index, which allowed correct predictions in 92% of patients with favorable outcome and in 85% of patients with unfavorable outcome (total predictive efficiency 88%).

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