Reference : Positron Emission Tomographic Study in Alzheimer's Disease and Pick's Disease
Scientific journals : Article
Human health sciences : Neurology
Positron Emission Tomographic Study in Alzheimer's Disease and Pick's Disease
Salmon, Eric mailto [Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
Franck, Georges [Université de Liège - ULiège > > Relations académiques et scientifiques (Médecine) >]
Archives of Gerontology and Geriatrics. Supplement
Yes (verified by ORBi)
[en] Tomography ; Alzheimer ; Pick
[en] Positron Emission Tomography has been used to compare patients with Alzheimer's disease and 3 patients with biopsy-proved Pick's disease to age-matched volunteers. In Alzheimer's disease, there was a trend to a decrease of the metabolism parallel to the severity of the affection. The hypometabolism was predominant in the temporo-parieto-occipital and the middle temporal regions. In 2 cases of Pick's disease with a classical "frontal syndrome", there was an important fronto-temporal hypometabolism, very suggestive of the diagnosis owing to both its location and intensity. A third patient presented with a slowly progressive dysphasia. A left perisylvian hypometabolism was observed before any evident anatomical abnormality. The clinical symptoms evolved to a dementia and the hypometabolism extended to both frontal lobes.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS

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