d-Aminopeptidase DppA

Remaut, Han; Goffin, Colette

doi:10.1016/B978-0-443-28849-4.00342-8

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d-Aminopeptidase DppA

Remaut, Han; Goffin, Colette

2025 • In Handbook of Proteolytic Enzymes: Metallopeptidases

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https://hdl.handle.net/2268/340302

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10.1016/B978-0-443-28849-4.00342-8

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Keywords :

Bacillus subtilis 168; d-alanyl-p-nitroanilide (d-Ala-pNa); D-Aminopeptidase DppA; Active site; Amino peptidase; Bacillus subtili 168; Bacillus Subtilis; D-alanyl-p-nitroanilide; d-Amino acids; D-aminopeptidase dppa; N terminus; p-Nitroanilide; Zinc metallopeptidase; Biochemistry, Genetics and Molecular Biology (all)

Abstract :

[en] The subject of this chapter is d-aminopeptidase DppA. DppA is a cocatalytic zinc metallopeptidase that releases a d-amino acid from the N-terminus of a peptide. It has been characterized as Bacillus subtilis. The aminopeptidase is a compartmentalizing enzyme and forms a homodecamer arranged in a barrel-shape, with two rings of five monomers stacked with the ten active sites pointing towards the large, central cavity. Biologically, the enzyme degrades the d-Ala-d-Ala dipeptide derived from the cell wall cross-linking peptide, and the gene is expressed early in sporulation.

Disciplines :

Biochemistry, biophysics & molecular biology
Microbiology

Author, co-author :

Remaut, Han; VIB-VUB Center for Structural Biology, Flanders Institute for Biotechnology, Vrije Universiteit Brussel, Etterbeek, Belgium

Goffin, Colette ; Université de Liège - ULiège > Département des sciences de la vie > Centre d'Ingénierie des Protéines (CIP)

Language :

English

Title :

d-Aminopeptidase DppA

Publication date :

2025

Main work title :

Handbook of Proteolytic Enzymes: Metallopeptidases

Publisher :

Elsevier

ISBN/EAN :

978-0-443-28849-4
978-0-443-28850-0

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https://api.elsevier.com/content/article/PII:B9780443288494003428?httpAccept=text/xml

Available on ORBi :

since 25 January 2026

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Cheggour, A., Fanuel, L., Duez, C., Joris, B., Bouillenne, F., Devreese, B., Van Driessche, G., Van Beeumen, J., Frère, J.-M., Goffin, C., 2000. The dppA gene of Bacillus subtilis encodes a new d-aminopeptidase. Mol. Microbiol. 38, 504-513, 10.1046/j.1365-2958.2000.02117.x, PMID: 11069674.
Mathiopoulos, C., Mueller, J.P., Slack, F.J., Murphy, C.G., Patankar, S., Bukusoglu, G., Sonenshein, A.L., 1991. A Bacillus subtilis dipeptide transport system expressed early during sporulation. Mol. Microbiol. 5, 1903-1913, 10.1111/j.1365-2958.1991.tb00814.x, PMID: 1766370.
Kunst, F., Ogasawara, N., Moszer, I., Albertini, A.M., Alloni, G., Azevedo, V., Bertero, M.G., Bessières, P., Bolotin, A., Borchert, S., Borriss, R., Boursier, L., Brans, A., Braun, M., Brignell, S.C., Bron, S., Brouillet, S., Bruschi, C.V., Caldwell, B., Capuano, V., Carter, N.M., Choi, S.K., Codani, J.J., Connerton, I.F., Daniel, R.A., Denizot, F., Devine, K.M., Düsterhöft, A., Ehrlich, S.D., Emmerson, P.T., Entian, K.D., Errington, J., Fabret, C., Ferrari, E., Foulger, D., Fritz, C., Fujita, M., Fujita, Y., Fuma, S., Galizzi, A., Galleron, N., Ghim, S.-Y., Glaser, P., Goffeau, A., Golightly, E.J., Grandi, G., Guiseppi, G., Guy, B.J., Haga, K., Haiech, J., Harwood, C.R., Hénaut, A., Hilbert, H., Holsappel, S., Hosono, S., Hullo, M.-F., Itaya, M., Jones, L., Joris, B., Karamata, D., Kasahara, Y., Klaerr-Blanchard, M., Klein, C., Kobayashi, Y., Koetter, P., Koningstein, G., Krogh, S., Kumano, M., Kurita, K., Lapidus, A., Lardinois, S., Lauber, J., Lazarevic, V., Lee, S.-M., Levine, A., Liu, H., Masuda, S., Mauël, C., Médigue, C., Medina, N., Mellado, R.P., Mizuno, M., Moestl, D., Nakai, S., Noback, M., Noone, D., O’Reilly, M., Ogawa, K., Ogiwara, A., Oudega, B., Park, S.-H., Parro, V., Pohl, T.M., Portetelle, D., Porwollik, S., Prescott, A.M., Presecan, E., Pujic, P., Purnelle, B., Rapoport, G., Rey, M., Reynolds, S., Rieger, M., Rivoltan, C., Rocha, E., Roche, B., Rose, M., Sadaie, Y., Sato, T., Scanlan, E., Schleich, S., Schroeter, R., Scoffone, F., Sekiguchi, J., Sekowska, A., Seror, S.J., Serror, P., Shin, B.-S., Soldo, B., Sorokin, A., Tacconi, E., Takagi, T., Takahashi, H., Takemaru, K., Takeuchi, M., Tamakoshi, A., Tanaka, T., Terpstra, P., Tognoni, A., Tosato, V., Uchiyama, S., Vandenbol, M., Vannier, F., Vassarotti, A., Viari, A., Wambutt, R., Wedler, E., Wedler, H., Weitzenegger, T., Winters, P., Wipat, A., Yamamoto, H., Yamane, K., Yasumoto, K., Yata, K., Yoshida, K., Yoshikawa, H.-F., Zumstein, E., Yoshikawa, H., Danchin, A., 1997. The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 390, 249-256, 10.1038/36786, PMID: 9384377.
Remaut, H., Bompard-Gilles, C., Goffin, C., Frère, J.M., Van Beeumen, J., 2001. Structure of the Bacillus subtilis d-aminopeptidase DppA reveals a novel self-compartmentalizing protease. Nat. Struct. Biol. 8, 674-678, 10.1038/90380, PMID: 11473256.
Larsen, C.N., Finley, D., 1997. Protein translocation channels in the proteasome and other proteases. Cell 91, 431-434, 10.1016/s0092-8674(00)80427-4, PMID: 9390550.
Lessard, I.A., Walsh, C.T., 1999. VanX, a bacterial d-alanyl-d-alanine dipeptidase: resistance, immunity, or survival function? Proc. Natl. Acad. Sci. USA 96, 11028-11032, 10.1073/pnas.96.20.11028, PMID: 10500118.
Asano, Y., Kato, Y., Yamada, A., Kondo, K., 1992. Structural similarity of D-aminopeptidase to carboxypeptidase DD and beta-lactamases. Biochemistry 31, 2316-2328, 10.1021/bi00123a016, PMID: 1540587.
Asano, Y., Ito, H., Dairi, T., Kato, Y., 1996. An alkaline d-stereospecific endopeptidase with beta-lactamase activity from Bacillus cereus. J. Biol. Chem. 271, 30256-30262, 10.1074/jbc.271.47.30256, PMID: 8939979.
Komeda, H., Asano, Y., 2000. Gene cloning, nucleotide sequencing, and purification and characterization of the D-stereospecific amino-acid amidase from Ochrobactrum anthropi SV3. Eur. J. Biochem. 267, 2028-2035, 10.1046/j.1432-1327.2000.01208.x, PMID: 10727942.
Fanuel, L., Goffin, C., Cheggour, A., Devreese, B., Van Driessche, G., Joris, B., Van Beeumen, J., Frère, J.M., 1999. The DmpA aminopeptidase from Ochrobactrum anthropi LMG7991 is the prototype of a new terminal nucleophile hydrolase family. Biochem. J. 341 (Pt 1), 147-155, PMID: 10377256.
Cue, D., Lam, H., Dillingham, R.L., Hanson, R.S., Flickinger, M.C., 1997. Genetic manipulation of Bacillus methanolicus, a gram-positive, thermotolerant methylotroph. Appl. Environ. Microbiol. 63, 1406-1420, 10.1128/aem.63.4.1406-1420.1997, PMID: 9097439.
Charlier, D., Kholti, A., Huysveld, N., Gigot, D., Maes, D., Thia-Toong, T.-L., Glansdorff, N., 2000. Mutational analysis of Escherichia coli PepA, a multifunctional DNA-binding aminopeptidase. J. Mol. Biol. 302, 411-426, 10.1006/jmbi.2000.4067, PMID: 10970742.
Sträter, N., Sherratt, D.J., Colloms, S.D., 1999. X-ray structure of aminopeptidase A from Escherichia coli and a model for the nucleoprotein complex in Xer site-specific recombination. EMBO J. 18, 4513-4522, 10.1093/emboj/18.16.4513, PMID: 10449417.