[en] The effects of Epidermal Growth Factor (EGF) on axonal regeneration of a sectioned sciatic nerve within collagen tubes were investigated in 15 rats. Following baseline electrophysiologic assessment, bilateral 7-mm nerve gaps were created and repaired by interposition of collagen tubes, into which EGF (left side) or type I collagen (right side) was instilled. After 4 or 8 weeks, axonal regeneration, measured by electrophysiologic and histologic means, was identical for the EGF and control legs. The conclusion is that EGF does not influence nerve regeneration within a collagen chamber.
Disciplines :
Neurology
Author, co-author :
Dubuisson, Annie ; Université de Liège - ULiège > Département des sciences cliniques > Neurochirurgie ; Department of Neurosurgery, Louisiana State University Medical Center, New Orleans
Beuermann, Roger; Service de Neurochirurgie, CHU Sart Tilman, Domaine Universitaire du Sart Tilman, 4000 Liege, Belgium
Kline, David; Service de Neurochirurgie, CHU Sart Tilman, Domaine Universitaire du Sart Tilman, 4000 Liege, Belgium
Language :
English
Title :
Sciatic nerve regeneration across gaps within collagen chambers: the influence of epidermal growth factor.
