Cortical Neuron Migration in Health and Disease

Javier Torrent, Míriam; Nguyen, Laurent

doi:10.1002/9781119860914.ch17

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Cortical Neuron Migration in Health and Disease

Javier Torrent, Míriam; Nguyen, Laurent

2023 • In Neocortical Neurogenesis in Development and Evolution

Editorial reviewed

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https://hdl.handle.net/2268/316547

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10.1002/9781119860914.ch17

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Keywords :

cellular crosstalk; cortical morphogenesis; interneurons; migration disorders; neuronal migration; projection neurons; Neuroscience (all)

Abstract :

[en] The cerebral cortex is an evolutionary advanced brain structure whose spatiotemporal patterning underlies the production of specific cell types that form neuronal networks essential for the emergence of higher cognitive functions. Cell migration is key to orchestrate the formation of the cortex as most of its cells are generated during embryogenesis by progenitors that reside at a distance. The cerebral cortex contains two major classes of neurons that are born in the germinal part of the cortical wall for the excitatory projection neurons (PNs) and in the ganglionic eminences and preoptic area for cortical interneurons (cINs). While PNs migrate perpendicularly to the ventricular surface along the fibers of radial glia cells (radial migration), cINs navigate within multiple tangential routes (tangential migration) that are remodeled as corticogenesis proceeds. Impairment in cell migration often underlies cortical malformations. Therefore, better understanding the events that control this process is key to shed light on the cellular and molecular drivers of these diseases. This chapter summarizes some of the key mechanisms that regulate neuronal migration and neurogenesis during cerebral cortex formation and discusses how their impairment leads to brain disorders.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Javier Torrent, Míriam ; Université de Liège - ULiège > GIGA > GIGA Neurosciences - Molecular Regulation of Neurogenesis

Nguyen, Laurent ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques

Language :

English

Title :

Cortical Neuron Migration in Health and Disease

Publication date :

2023

Main work title :

Neocortical Neurogenesis in Development and Evolution

Publisher :

wiley

ISBN/EAN :

978-1-119-81982-0
978-1-119-86080-8

Peer reviewed :

Editorial reviewed

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https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781119860914.ch17

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since 22 April 2024

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