Continuous‐Flow Multistep Synthesis of Active Pharmaceutical Ingredients

Chen, Yuesu; Monbaliu, Jean-Christophe

doi:10.1002/9783527824595.ch7

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Continuous‐Flow Multistep Synthesis of Active Pharmaceutical Ingredients

Chen, Yuesu; Monbaliu, Jean-Christophe

2022 • In Alza, Esther (Ed.) Flow and Microreactor Technology in Medicinal Chemistry

Editorial reviewed

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https://hdl.handle.net/2268/298843

DOI
10.1002/9783527824595.ch7

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Keywords :

Flow chemistry; Microreactor; Pharmaceutical; API; Organic Synthesis

Abstract :

[en] This chapter introduces the application of continuous-flow technology in the concatenated multistep synthesis of active pharmaceutical ingredients (APIs) and related compounds. Starting from the chemical generators, the simplest two-step reaction, the basic principles, and benefits of performing two reaction steps in one flow are introduced. In the following sections, selected worked examples of multistep flow synthesis of drugs and drug-related molecules are introduced in the sequence of increasing complexity (synthetic steps). New technologies enabling the process control and automation in the multistep synthesis of APIs have also been visited.

Research Center/Unit :

Center for Integrated Technology and Organic Synthesis

Disciplines :

Chemistry

Author, co-author :

Chen, Yuesu ; Université de Liège - ULiège > Molecular Systems (MolSys)

Monbaliu, Jean-Christophe ; Université de Liège - ULiège > Molecular Systems (MolSys)

Language :

English

Title :

Continuous‐Flow Multistep Synthesis of Active Pharmaceutical Ingredients

Publication date :

17 June 2022

Main work title :

Flow and Microreactor Technology in Medicinal Chemistry

Editor :

Alza, Esther; Alza & Associates S.L. Sustainable Chemistry Consulting

Publisher :

Wiley-VCH, Weinheim, Germany

Edition :

ISBN/EAN :

9783527824595

Collection name :

Methods and Principles in Medicinal Chemistry

Collection ISSN :

1865-0562

Pages :

233-268

Peer reviewed :

Editorial reviewed

Additional URL :

https://onlinelibrary.wiley.com/doi/pdf/10.1002/9783527824595.ch7

Available on ORBi :

since 16 January 2023

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