Biphasic locomotor effects of the dopamine D-sub-1 agonist SKF 38393 and their attenuation in non-habituated mice

Tirelli, Ezio; Terry, P.

doi:10.1007/BF02246952

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Biphasic locomotor effects of the dopamine D-sub-1 agonist SKF 38393 and their attenuation in non-habituated mice

Tirelli, Ezio; Terry, P.

1993 • In Psychopharmacology, 110 (1-2), p. 69-75

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https://hdl.handle.net/2268/29516

DOI
10.1007/BF02246952

PubMed
7870901

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Keywords :

dépression; test

Abstract :

[en] Examined the locomotor stimulatory effects of the dopamine D-sub-1 receptor partial agonist SKF 38393 in male C57B1/6J mice. Non-habituated mice showed marked dose-related (3-300 mg/kg, subcutaneously) locomotor stimulation. The time-course effect was biphasic at very high doses (100-300 mg/kg), with dose-related locomotor depression followed by dose-related long-term hyperlocomotion. For all doses, locomotor effects were detectable throughout the 4-hr test period. To determine whether these effects were mediated by D-sub-1 receptor stimulation, effects of SKF 38393 were assessed in combination with behaviorally inactive and active doses (0.1 and 0.2 mg/kg, respectively) of the selective D-sub-1 receptor antagonist SCH 39166. Both doses of SCH 39166 attenuated the hyperlocomotion induced by 30 mg/kg of the agonist to a similar degree. However, neither dose was able to reverse either the depressant or the stimulatory effects of 300 mg/kg SKF 38393. ((c) 1997 APA/PsycINFO, all rights reserved)

Research Center/Unit :

Centre de Neurosciences Cognitives et Comportementales - ULiège

Disciplines :

Neurosciences & behavior

Author, co-author :

Tirelli, Ezio ; Université de Liège - ULiège > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér.

Terry, P.

Language :

English

Title :

Biphasic locomotor effects of the dopamine D-sub-1 agonist SKF 38393 and their attenuation in non-habituated mice

Publication date :

1993

Journal title :

Psychopharmacology

ISSN :

0033-3158

eISSN :

1432-2072

Publisher :

Springer, Germany

Volume :

110

Issue :

1-2

Pages :

69-75

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 26 November 2009

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