Biphasic locomotor effects of the dopamine D-sub-1 agonist SKF 38393 and their attenuation in non-habituated mice

Tirelli, Ezio; Terry, P.

doi:10.1007/BF02246952

No full text

Article (Scientific journals)

Biphasic locomotor effects of the dopamine D-sub-1 agonist SKF 38393 and their attenuation in non-habituated mice

Tirelli, Ezio; Terry, P.

1993 • In Psychopharmacology, 110 (1-2), p. 69-75

Peer Reviewed verified by ORBi

Permalink
https://hdl.handle.net/2268/29516

DOI
10.1007/BF02246952

PubMed
7870901

Files (0)Send to Details Statistics Bibliography Similar publications

Files

Full Text

No document available.

Send to

RIS BibTex APA Chicago Permalink X Linkedin

Details

Keywords :

dépression; test

Abstract :

[en] Examined the locomotor stimulatory effects of the dopamine D-sub-1 receptor partial agonist SKF 38393 in male C57B1/6J mice. Non-habituated mice showed marked dose-related (3-300 mg/kg, subcutaneously) locomotor stimulation. The time-course effect was biphasic at very high doses (100-300 mg/kg), with dose-related locomotor depression followed by dose-related long-term hyperlocomotion. For all doses, locomotor effects were detectable throughout the 4-hr test period. To determine whether these effects were mediated by D-sub-1 receptor stimulation, effects of SKF 38393 were assessed in combination with behaviorally inactive and active doses (0.1 and 0.2 mg/kg, respectively) of the selective D-sub-1 receptor antagonist SCH 39166. Both doses of SCH 39166 attenuated the hyperlocomotion induced by 30 mg/kg of the agonist to a similar degree. However, neither dose was able to reverse either the depressant or the stimulatory effects of 300 mg/kg SKF 38393. ((c) 1997 APA/PsycINFO, all rights reserved)

Research Center/Unit :

Centre de Neurosciences Cognitives et Comportementales - ULiège

Disciplines :

Neurosciences & behavior

Author, co-author :

Tirelli, Ezio ; Université de Liège - ULiège > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér.

Terry, P.

Language :

English

Title :

Biphasic locomotor effects of the dopamine D-sub-1 agonist SKF 38393 and their attenuation in non-habituated mice

Publication date :

1993

Journal title :

Psychopharmacology

ISSN :

0033-3158

eISSN :

1432-2072

Publisher :

Springer, Germany

Volume :

110

Issue :

1-2

Pages :

69-75

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 26 November 2009

Statistics

Number of views

52 (0 by ULiège)

Number of downloads

0 (0 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

Arnt J. (1985) Behavioral stimulation is induced by separate dopamine D1 and D2 receptor sites in reserpine-pretreated but not in normal rats. Eur J Pharmacol 113:79-88.
Arnt J., Hyttel J. (1988) Behavioral differentiation between effects elicited at dopamine D1 and D2 receptors in rats with normosensitive DA receptors. Pharmacopsychiatry 21:24-27.
Arnt J., Hyttel J., Perregaard J. (1987) Dopamine D-1 receptor agonists combined with the selective D-2 agonist quinpirole facilitate the expression of oral stereotyped behaviour in rats. Eur J Pharmacol 133:137-145.
Arnt J., Bogeso K.P., Hyttel J., Meier E. (1988) Relative dopamine D1 and D2 receptor affinity and efficacy determine whether dopamine agonists induce hyperactivity or oral stereotypy in rats. Pharmacol Toxicol 62:121-130.
Belcheva I., Bryer J.B., Starkstein S.E., Honig M., Moran T.H., Robinson R.G. (1990) Hemispheric asymmetry in behavioral response to D1 and D2 receptor agonists in the nucleus accumbens. Brain Res 533:286-291.
Braun A.R., Chase T.N. (1986) Obligatory D-1/D-2 receptor interactions in the generation of dopamine agonist related behaviors. Eur J Pharmacol 131:301-306.
Breese G.R., Duncan G.E., Napier T.C., Bondy S.C., Iorio L.C., Mueller R.A. (1987) 6-Hydroxydopamine treatments enhance behavioral response to intracerebral microinjections of D1 and D2 agonists into the nucleus accumbens and striatum without changing dopamine antagonist binding. J Pharmacol Exp Ther 240:167-176.
Brent P.J. (1991) Behavioural effects of selective dopamine D-1 and D-2 agonists and antagonists in guinea pigs. Psychopharmacology 104:201-207.
Bruhwyler J., Chleide E., Liegeois J-F, Delarge J., Mercier M. (1991) Effects of specific dopaminergic agonists and antagonists in the open-field test. Pharmacol Biochem Behav 39:367-371.
Cameron D.L., Crosbie J., Crocker A.D. (1988) A fixed interval momentary sampling method for assessing ongoing behaviors induced by dopamine receptor agonists. Prog Neuropsychopharmacol Biol Psychiatry 12:595-606.
Chagraoui A., Vasse M., Protais P. (1990) Effects of chronic treatments with amineptine and desipramine on motor responses involving dopaminergic systems. Psychopharmacology 102:201-206.
Chandler C.J., Wohab W., Starr B.S., Starr (1990) Motor depression: a new role for D1 receptors?. Neuroscience 38:437-445.
Chipkin R.E., Iorio L.C., Coffin V.L., McQuade R.D., Berger J.G., Barnett A. (1988) Pharmacological profile of SCH 39166: a dopamine D1 selective benzonaphthazepine with potential antipsychotic activity. J Pharmacol Exp Ther 247:1093-1102.
Clarke D., White F.J. (1987) Review: D1 dopamine receptor — the search for a function: a critical evaluation of the D1/D2 dopamine receptor classification and its functional implications. Synapse 1:347-388.
Collins P., Broekkamp C.L.E., Jenner P., Marsden C.D. (1991) Drugs acting at D-1 and D-2 dopamine receptors induce identical purposeless chewing in rats which can be differentiated by cholinergic manipulation. Psychopharmacology 103:503-512.
Darney K.J., Lewis M.H., Brewster W.K., Nichols D.E., Mailman R.B. (1991) Behavioral effects in the rat of dihydrexidine, a high potency full efficacy D1 dopamine receptor agonist. Neuropsychopharmacology 5:187-195.
DeNinno M.P., Schoenleber R., MacKenzie R., Britton D.R., Asin K.E., Briggs C., Trugman J.M., Ackerman M., Artman L., Bednarz L., Bhatt R., Curzon P., Gomez E., Kang C.H., Stittsworth J., Kebabian J.W. (1991) A68930: a potent agonist selective for the D1 receptor. Eur J Pharmacol 199:209-219.
Dreher J.K., Jackson D.M. (1989) Role of dopamine D1 and D2 receptors in mediating locomotor activity elicited from the nucleus accumbens of rats. Brain Res 487:267-277.
Eilam D., Clements K.V.A., Szechtman H. (1991) Differential effects of D1 and D2 dopamine agonists on stereotyped locomotion in rats. Behav Brain Res 45:117-124.
Fletcher G.H., Starr (1985) SKF 38393 and apomorphine modify locomotion and exploration in rats placed on a holeboard by separate actions at dopamine D-1 and D-2 receptors. Eur J Pharmacol 117:381-385.
Gandolfi O., Dall'olio R., Vaccheri A., Roncada P., Montanaro N. (1988) Responses to selective D-1 and D-2 agonists after repeated treatment with selective D-1 and D-2 antagonists. Pharmacol Biochem Behav 30:463-469.
Hoffman D.C., Beninger R.J. (1985) The D1 dopamine receptor antagonist SCH 23390 reduces locomotor activity and rearing in rats. Pharmacol Biochem Behav 22:341-342.
Hoffman D.C., Beninger R.J. (1989) Preferential stimulation of D1 or D2 receptors disrupts food-rewarded operant responding in rats. Pharmacol Biochem Behav 34:923-925.
Johnsen P.A., Hu X-T, White F.J. (1991) Relationship between D1 receptors, adenylate cyclase, and the electrophysiological responses of rat nucleus accumbens neurons. Journal of Neural Transmission 86:97-113.
Johansson P., Levin E., Gunne L., Ellison G. (1987) Opposite effects of a D1 and a D2 agonist on oral movements in rats. Eur J Pharmacol 134:82-88.
Kamien J.B., Goldberg L.I., Woolverton W.L. (1987) Discriminative stimulus properties of D1 and D2 dopamine agonists in rats. J Pharmacol Exp Ther 242:804-811.
Kelley A.E., Delfs J.M., Chu B. (1990) Neurotoxicity induced by the D-1 agonist SKF 38393 following microinjection into rat brain. Brain Res 532:342-346.
Kirk R.E. Experimental design: procedures for the behavioral sciences, 2nd edn., Brooks Cole, Monterey, CA; 1982.
Mackintosh J.H., Chance A., Silverman A.P. (1977) The contribution of ethological techniques to the study of drug effects. Handbook of psychopharmacology, vol 7 , L.L., Iversen, S.D., Iversen, S.H., Snyder, Plenum Press, New York; 3-34.
Mazurski E.J., Beninger R.J. (1991) Effects of selective drugs for dopaminergic D1 and D2 receptors on conditioned locomotion in rats. Psychopharmacology 105:107-112.
Molloy A.G., O'Boyle K.M., Pugh M.T., Waddington J.L. (1986) Locomotor behaviors in response to new selective D-1 and D-2 dopamine receptor agonists, and the influence of selective antagonists. Pharmacol Biochem Behav 25:249-253.
Molloy A.G., Waddington J.L. (1984) Dopaminergic behavior stereospecifically promoted by the D-1 agonist R-SK&F 38393 and selectively blocked by the D-1 antagonist SCH 23390. Psychopharmacology 82:409-410.
Molloy A.G., Waddington J.L. (1985) Sniffing, rearing and locomotor responses to the D-1 dopamine agonist R-SK&F 38393 and to apomorphine: differential interactions with the selective D-1 and D-2 antagonists SCH 23390 and metoclopramide. Eur J Pharmacol 108:305-308.
Molloy A.G., Waddington J.L. (1987) Assessment of grooming and other behavioural responses to the D-1 receptor agonist SK&F 38393 and its R- and S-enantiomers in intact adult rats. Psychopharmacology 92:164-168.
Monti J.M., Fernandez M., Jantos H. (1990) Sleep during acute dopamine D1 agonist or D1 antagonist SCH 23390 administration in rats. Neuropsychopharmacology 3:153-162.
Morelli M., DiChiara G. (1985) Catalepsy induced by SCH 23390 in rats. Eur J Pharmacol 117:179-185.
Murray A.M., Waddington J.L. (1989) The induction of grooming and vacuous chewing by a series of selective D-1 dopamine receptor agonists: two directions of D-1:D-2 interaction. Eur J Pharmacol 160:377-384.
Murray A.M., Waddington J.L. (1990) New putative selective agonists at the dopamine D-1 receptor: behavioural and neurochemical comparison of CY 208–243 with SK&F 101384 and SK&F 103243. Pharmacol Biochem Behav 35:105-110.
Rosengarten H., Schweitzer J.W., Friedhoff A.J. (1983) Induction of oral dyskinesias in naive rats by D-1 stimulation. Life Sci 33:2479-2482.
Rosengarten H., Schweitzer J.W., Friedhoff A.J. (1986) Selective dopamine D2 receptor reduction enhances a D1 mediated oral dyskinesia in rats. Life Sci 39:29-35.
Rusk I.N., Cooper S.J. (1989) The selective dopamine D1 agonist SK&F 38393: its effects on palatability- and deprivation-induced feeding, and operant responding for food. Pharmacol Biochem Behav 34:17-22.
Serra G., Collu M., D'Aquila P.S., De Montis G.M., Gessa G.L. (1990) Possible role of the D1 receptor in the behavioural supersensitivity to dopamine agonists induced by chronic treatment with antidepressants. Brain Res 527:234-243.
Setler P.E., Sarau H.M., Zirckle, Saunders H.J. (1978) The central effects of a novel dopamine agonist. Eur J Pharmacol 50:419-430.
Shannon H.E., Peters S.C. (1990) A comparison of the effects of cholinergic and dopaminergic agents on scopolamine-induced hyperactivity in mice. J Pharmacol Exp Ther 255:549-553.
Shannon H.E., Bemis K.G., Peters S.C. (1991) Potency and efficacy of dopamine agonists in mouse strains differing in dopamine cell and receptor number. Pharmacol Biochem Behav 40:103-107.
Skrinskaya J.A., Nikulina E.M., Popova N.K. (1992) Role of genotype in brain dopamine metabolism and dopamine dependent behavior of mice. Pharmacol Biochem Behav 42:261-267.
Starr B.S., Starr (1986) Grooming in the mouse is stimulated by the dopamine D1 agonist SKF 38393 and by low doses of the D1 antagonist SCH 23390, but is inhibited by dopamine D2 agonists, D2 antagonists and high doses of SCH 23390. Pharmacol Biochem Behav 24:837-839.
Starr B.S., Starr (1986) Differential effects of dopamine D1 agonists and antagonists on velocity of movement, rearing and grooming in the mouse. Neuropharmacology 25:455-463.
Starr B.S., Starr (1987) Behavioral interactions involving D1 and D2 dopamine receptors in non-habituated mice. Neuropharmacology 26:613-619.
Starr B.S., Starr, Kilpatrick J.C. (1987) Behavioural role of dopamine D1 receptors in the reserpine treated mouse. Neuroscience 22:179-188.
.
Trampus M., Ferri N., Monopoli A., Ongini E. (1991) The dopamine D1 receptor is involved in the regulation of REM sleep in the rat. Eur J Pharmacol 194:189-194.
Waddington J.L., O'Boyle K.M. (1989) Drugs acting on brain dopamine receptors: a conceptual re-evaluation five years after the first selective D-1 antagonist. Pharmacol Ther 43:1-52.
Waley J.K., Hunt M.E., McQuade R.D., Alburges M.B. (1991) [³H]SCH39166, a D1 dopamine receptor antagonist: binding characteristics and localization. Exp Neurol 111:145-151.
White F.J., Bednarz L.M., Wachtel S.R., Hjorth S., Brooderson R.J. (1988) Is stimulation of both D1 and D2 receptors necessary for the expression of dopamine mediated behaviors?. Pharmacol Biochem Behav 30:189-193.
Witkin J.M., Schindler C.W., Tella S.R., Goldberg S.R. (1991) Interaction of haloperidol and SCH 23390 with cocaine and dopamine receptor subtype-selective agonists on schedule-controlled behavior of squirrel monkeys. Psychopharmacology 104:425-431.
Zarrindast, Elliasi A. (1991) Differential effects of dopamine agonists on locomotion in intact and reserpine-treated mice. Gen Pharmacol 22:1027-1031.
Zhou L-W, Qin Z-H, Weiss B. (1991) Downregulation of stereo-typed behavior and production of latent locomotor behaviors in mice treated continuously with quinpirole. Neuropsychopharmacology 4:47-55.