Reference : Short-, medium-, and long-term effects of prenatal oxazepam on neurobehavioural devel...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/29507
Short-, medium-, and long-term effects of prenatal oxazepam on neurobehavioural development of mice
English
Alleva, E. [> > > >]
Laviola, G. [> > > >]
Tirelli, Ezio mailto [Université de Liège - ULiège > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér. >]
Bignami, G. [> > > >]
1985
Psychopharmacology
Springer Verlag
87
4
434-441
Yes (verified by ORBi)
International
0033-3158
1432-2072
Berlin
Germany
[en] Oxazepam was given to nulliparous CD-1 mice on Days 12-26 of pregnancy, and the development and young adult behavior of the offspring were studied. Exp I, using 5, 15, and 50 mg/kg oral doses given twice daily, showed a dose-dependent retardation of postnatal development of several responses such as righting, barholding, limb placing, and auditory startle. These changes were maximal in the 1st 2 postnatal weeks and then were markedly attenuated, or disappeared, being apparently related to a temporary retardation of body growth. A reduction of locomotor activity at 60 days was found only in the 50 mg/kg group. In Exps II and III, prenatal oxazepam reduced open-field activity at 14-26 days and attenuated the hyperactivity induced by dl-amphetamine (d,l-amphetamine) sulfate (2 mg/kg, intraperitoneally). Exp III, using a cross-fostering procedure, showed that postnatal maternal effects were not responsible for the aforementioned changes. Exp II also investigated the acquisition of several go/no go avoidance discriminations. The main effect of prenatal oxazepam was an impairment of active avoidance responding, while the treatment effects on overall discrimination performance were less marked and limited to the later stages of training. (29 ref) ((c) 1997 APA/PsycINFO, all rights reserved)
Centre de Neurosciences Cognitives et Comportementales
http://hdl.handle.net/2268/29507

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