No full text
Article (Scientific journals)
Oxytocin attenuates tolerance not only to the hypothermic but also to the myorelaxant and akinesic effects of ethanol in mice
Jodogne, C.; Tirelli, Ezio; Klingbiel, P. et al.
1991In Pharmacology, Biochemistry and Behavior, 40 (2), p. 261-265
Peer Reviewed verified by ORBi
 

Files


Full Text
No document available.

Send to



Details



Abstract :
[en] Inhibition of ethanol tolerance by oxytocin has been demonstrated previously using the hypothermic effect only. The purpose of the present experiment was to investigate the effect of oxytocin on the development of tolerance to ethanol-induced hypothermia, myorelaxation and akinesia in mice. Four groups of mice received daily intraperitoneal injections of saline or oxytocin (0.005 mg) plus saline or ethanol (2 g/kg). The peptide was administered 2 hours before ethanol. For five consecutive days, temperature measurements were performed 20 minutes before and after ethanol injection. Myorelaxation and akinesia were evaluated following the second temperature measure. Oxytocin pretreatment, which had no intrinsic effects, resulted in a robust selective attenuation of tolerance to ethanol-induced hypothermia, myorelaxation and akinesia. These results suggest that the mechanisms for peptide modulation are common to these three typical effects of ethanol.
Research center :
Centre de Neurosciences Cognitives et Comportementales - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Jodogne, C.
Tirelli, Ezio ;  Université de Liège - ULiège > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér.
Klingbiel, P.
Legros, Jean-Jacques ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Language :
English
Title :
Oxytocin attenuates tolerance not only to the hypothermic but also to the myorelaxant and akinesic effects of ethanol in mice
Publication date :
October 1991
Journal title :
Pharmacology, Biochemistry and Behavior
ISSN :
0091-3057
Publisher :
Ankho International, United States - New York
Volume :
40
Issue :
2
Pages :
261-265
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 26 November 2009

Statistics


Number of views
70 (0 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
24
Scopus citations®
without self-citations
22
OpenCitations
 
21

Bibliography


Similar publications



Contact ORBi