[en] Inhibition of ethanol tolerance by oxytocin has been demonstrated previously using the hypothermic effect only. The purpose of the present experiment was to investigate the effect of oxytocin on the development of tolerance to ethanol-induced hypothermia, myorelaxation and akinesia in mice. Four groups of mice received daily intraperitoneal injections of saline or oxytocin (0.005 mg) plus saline or ethanol (2 g/kg). The peptide was administered 2 hours before ethanol. For five consecutive days, temperature measurements were performed 20 minutes before and after ethanol injection. Myorelaxation and akinesia were evaluated following the second temperature measure. Oxytocin pretreatment, which had no intrinsic effects, resulted in a robust selective attenuation of tolerance to ethanol-induced hypothermia, myorelaxation and akinesia. These results suggest that the mechanisms for peptide modulation are common to these three typical effects of ethanol.
Research Center/Unit :
Centre de Neurosciences Cognitives et Comportementales - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Jodogne, C.
Tirelli, Ezio ; Université de Liège - ULiège > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér.
Klingbiel, P.
Legros, Jean-Jacques ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Language :
English
Title :
Oxytocin attenuates tolerance not only to the hypothermic but also to the myorelaxant and akinesic effects of ethanol in mice
Dudek, Phillips (1990) Distinction among sedative, disinhibitory, and ataxic properties of ethanol in inbred and selectively bred mice. Psychopharmacology (Berlin) 101:93-99.
Durcan, Lister, Linnoila (1989) Behavioral effects of alpha2 adrenoceptor antagonists and their interactions with ethanol in tests of locomotion, exploration and anxiety in mice. Psychopharmacology (Berlin) 97:189-193.
Hoffman (1982) Structural requirements for neurohypophyseal peptide maintenance of ethanol tolerance. Pharmacol. Biochem. Behav. 17:685-690.
Hoffman, Ritzmann, Tabakoff (1980) Neurohypophyseal peptide influences on ethanol tolerance and acute effects of ethanol. Pharmacol. Biochem. Behav. 13:279-284.
Lê, Khanna, Leblanc (1981) Effect of modification of brain serotonin (5-HT) norepinephrine (NE) and dopamine (DA) on ethanol tolerance. Psychopharmacology 75:231-235.
Legros, Deconinck, Willems, Roth, Pelc, Brauman, Verbanck (1983) Increase of neurophysin II serum levels in chronic alcoholic patients: Relationship with alcohol consumption and alcoholism blood markers during withdrawal therapy. J. Endocrinol. Metab. 56:871-875.
Liljequist, Engel (1982) Effects of GABAergic agonists and antagonists on various ethanol-induced behavioural changes. Psychopharmacology (Berlin) 78:71-75.
Peris, Cunningham (1987) Stress enhances the development of tolerance to the hypothermic effect of ethanol. Alcohol Drug Res. 7:187-193.
Pucilowski, Kotowski, Trzaskowa (1985) The effect of oxytocin and fragment (MIF-1) on the development of tolerance to hypothermic and hypnotic action of ethanol in the rat. Peptides 6:7-10.
Rigter, Crabbe (1980) Alcohol: modulation of tolerance by neuropeptides. Psychopharmacology of alcohol , M. Sandler, Raven Press, New York; 179-189.
Ritzmann, Colbern, Zimmerman, Krivoy (1984) Neurohypopyseal hormones in tolerance and physical dependence. Pharmacol. Ther. 23:281-312.
Sinclair (1988) Multiple t-tests are appropriate in science. Trends Pharmacol. Sci. 9:12-13.
Smoothy, Berry (1984) Alcohol increases both locomotion and immobility in mice: an ethological analysis of spontaneous motor activity. Psychopharmacology (Berlin) 83:272-276.
Szabó, Kovács, Baláspiri, Telegdy (1986) D-pipecolylleucyl-glycinamide, a substituted tripeptide analogue of the C-terminal part of oxytocin, influences tolerance and dependence on ethanol in mice. Alcohol Drug Res. 7:99-105.
Szabó, Kovács, Székeli, Baláspiri, Telegdy (1987) C-terminal fragments of oxytocin (prolyl-leucyl-glycinamide and Z-prolyl-D-leucine) attenuate the development of tolerance to ethanol. Acta Physiol. Hung. 69:115-122.
Szabó, Kovács, Székeli, Telegdy (1985) The effects of neurohypophyseal hormones on tolerance to the hypothermic effect of ethanol. Alcohol 2:567-574.
Szabó, Kovács, Telegdy (1987) Neurohypophyseal peptides and ethanol tolerance and dependence. Front. Horm. Res. 15:128-137.
Székeli, Szabó, Kovács, Telegdy (1984) Effects of neurohypophyseal peptides hormones on ethanol tolerance. Acta Physiol. Hung. 53:279.
Tabakoff, Ritzmann (1977) The effectsof 6-hydroxydopamine on tolerance to and dependence on ethanol. J. Pharmacol. Exp. Ther. 203:319-332.
Winer Statistical principles in experimental design, MacGraw Hill, New York; 1971.
