Reference : Gamma-aminobutyric acid-sub(A) agonists differentially gnawing induced by indirect-ac...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Gamma-aminobutyric acid-sub(A) agonists differentially gnawing induced by indirect-acting dopamine agonists in C57BL/6J mice
Tirelli, Ezio mailto [Université de Liège - ULiège > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér. >]
Geter-Douglass, B. [> > > >]
Witkin, J. M. [> > > >]
Journal of Pharmacology and Experimental Therapeutics
American Society for Pharmacology and Experimental Therapeutics
Yes (verified by ORBi)
[en] Evaluated the interaction of either gaboxadol HCl (THIP) or muscimol, both gamma-aminobutyric acid (GABA) type A agonists, with indirect-acting dopamine agonists (DAGs) methylphenidate, (+)-amphetamine, metamphetamine, amfonelic acid, indatraline, nomifensine, diclofensine, mazindol, and GBR 12935 and with direct-acting DAGs WIN 35,428, bupropion, GBR 12909, and cocaine. 1,832 male C57BL/6J mice were given either with saline or 1 of the doses of THIP or muscimol before an injection of a dopamine agonist. Gnawing on corrugated packing paper was measured. Results showed that: (1) indirect- but not direct-acting DAGs induced gnawing, (2) gnawing induced by indirect-acting DAGs GBR 12935, nomifensine and mazindol was potentiated in mice in which GABA type A receptors were stimulated either by THIP or muscimol, and (3) indirect DAGs had a differential sensitivity to the effects of THIP and muscimol. ((c) 1998 APA/PsycINFO, all rights reserved)
Centre de Neurosciences Cognitives et Comportementales

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