[en] Characterized the behavioral and pharmacological mechanisms associated with cocaine potentiation of apomorphine (AP)-induced gnawing (AIG) in male C57BL/6J mice. Results showed that (-)-cocaine enhanced AIG at doses devoid of effects on gnawing when given alone; (+)-cocaine or (-)-cocaine methiodide were also devoid of effects. Lidocaine, a local anesthetic without prominent dopaminergic actions, augmented the gnawing response to AP without increasing climbing or gnawing when given alone. (+)-Amphetamine enhanced AIG gnawing but only at a high dose that increased gnawing by itself. The selective dopamine (DA) uptake blocker, GBR 12909, augmented AIG by itself; however, it increased climbing at doses that augmented the gnawing response. These data indicate that the cocaine-augmented gnawing response to AP may be due to blockade of DA uptake and or the local anesthetic actions of cocaine. ((c) 1997 APA/PsycINFO, all rights reserved)
Research center :
Centre de Neurosciences Cognitives et Comportementales - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Tirelli, Ezio ; Université de Liège - ULiège > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér.
Witkin, J. M.
Language :
English
Title :
Pharmacological characterization of the enhancement of apomorphine-induced gnawing in mice by cocaine
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