Pharmacological characterization of the enhancement of apomorphine-induced gnawing in mice by cocaine

Tirelli, Ezio; Witkin, J. M.

doi:10.1016/0091-3057(96)00067-6

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Pharmacological characterization of the enhancement of apomorphine-induced gnawing in mice by cocaine

Tirelli, Ezio; Witkin, J. M.

1996 • In Pharmacology, Biochemistry and Behavior, 55 (1), p. 135-140

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10.1016/0091-3057(96)00067-6

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8870049

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Abstract :

[en] Characterized the behavioral and pharmacological mechanisms associated with cocaine potentiation of apomorphine (AP)-induced gnawing (AIG) in male C57BL/6J mice. Results showed that (-)-cocaine enhanced AIG at doses devoid of effects on gnawing when given alone; (+)-cocaine or (-)-cocaine methiodide were also devoid of effects. Lidocaine, a local anesthetic without prominent dopaminergic actions, augmented the gnawing response to AP without increasing climbing or gnawing when given alone. (+)-Amphetamine enhanced AIG gnawing but only at a high dose that increased gnawing by itself. The selective dopamine (DA) uptake blocker, GBR 12909, augmented AIG by itself; however, it increased climbing at doses that augmented the gnawing response. These data indicate that the cocaine-augmented gnawing response to AP may be due to blockade of DA uptake and or the local anesthetic actions of cocaine. ((c) 1997 APA/PsycINFO, all rights reserved)

Research Center/Unit :

Centre de Neurosciences Cognitives et Comportementales - ULiège

Disciplines :

Neurosciences & behavior

Author, co-author :

Tirelli, Ezio ; Université de Liège - ULiège > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér.

Witkin, J. M.

Language :

English

Title :

Pharmacological characterization of the enhancement of apomorphine-induced gnawing in mice by cocaine

Publication date :

1996

Journal title :

Pharmacology, Biochemistry and Behavior

ISSN :

0091-3057

Publisher :

Elsevier, Tarrytown, United States - New York

Volume :

Issue :

Pages :

135-140

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 25 November 2009

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