Reference : Ultrastructural study of the relationships between the various nucleolar components i...
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Ultrastructural study of the relationships between the various nucleolar components in Ehrlich tumour and HEp-2 cell nucleoli after acetylation.
Thiry, Marc mailto [Université de Liège - ULiège > Département des sciences de la vie > Biologie cellulaire >]
Goessens, Guy mailto [Université de Liège - ULiège > Services généraux (Faculté des sciences) > Relations académiques et scientifiques (Sciences) >]
Experimental Cell Research
Academic Press
Yes (verified by ORBi)
[en] Acetylation ; Animals ; Carcinoma, Ehrlich Tumor ; Carcinoma, Squamous Cell ; Cell Line ; Cell Nucleolus/physiology/ultrastructure ; Cells, Cultured ; Chromatin/ultrastructure ; Humans ; Interphase ; Mice ; Microscopy, Electron
[en] In the present study, we analysed the relationships between various nucleolar components in Ehrlich tumour and HEp-2 cells, using acetylation. Under these conditions, we found contacts between the condensed intranucleolar chromatin and the fibrillar centre, illustrating the continuity between the DNA present inside the fibrillar centre and that of condensed associated chromatin. We also found that although the dense fibrillar component is usually situated at the periphery of the fibrillar centre, it is sometimes found inside the centre. On the other hand, the layer of dense fibrils bordering the fibrillar centre is interrupted by nucleolar interstices. In addition, in HEp-2 cell nucleoli with a reticulated appearance, the numerous small fibrillar centres are bound together by strands of dense fibrillar component. These observations are discussed in terms of relationships between nucleolar ultrastructure and function(s).

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