Co-operative binding of the glucocorticoid receptor DNA binding domain is one of at least two mechanisms for synergism.

Baniahmad, Claudia; Muller, Marc; Altschmied, Joachim; Renkawitz, Rainer

doi:10.1016/0022-2836(91)90202-H

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Co-operative binding of the glucocorticoid receptor DNA binding domain is one of at least two mechanisms for synergism.

Baniahmad, Claudia; Muller, Marc; Altschmied, Joachim et al.

1991 • In Journal of Molecular Biology, 222 (2), p. 155-65

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https://hdl.handle.net/2268/29024

DOI
10.1016/0022-2836(91)90202-H

PubMed
1960719

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Keywords :

Base Sequence; DNA Mutational Analysis; DNA-Binding Proteins/metabolism; Gene Expression Regulation; Molecular Sequence Data; Plasmids; Receptors, Glucocorticoid/metabolism; Recombinant Proteins; Regulatory Sequences, Nucleic Acid; Structure-Activity Relationship; Transcription, Genetic

Abstract :

[en] Steroid induction of responsive genes functions through the synergistic activity of steroid receptor binding sequences with adjacent binding sites either for other transcription factors or for further steroid receptors. Analysis of the human glucocorticoid receptor revealed that the DNA-binding domain of the receptor is sufficient to mediate co-operative binding to adjacent receptor binding sites. This is a novel feature of the domain in addition to its DNA-binding, trans-activating and trans-repressing properties. Chimaeric proteins containing the N- or C-terminal receptor halves fused to the GAL4 DNA-binding domain do not co-operate in DNA-binding, however they do functionally synergize. Thus, at least two mechanisms contribute to the synergism of the human glucocorticoid receptor bound to two adjacent receptor binding sites.

Disciplines :

Genetics & genetic processes

Author, co-author :

Baniahmad, Claudia

Muller, Marc ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire

Altschmied, Joachim

Renkawitz, Rainer

Language :

English

Title :

Co-operative binding of the glucocorticoid receptor DNA binding domain is one of at least two mechanisms for synergism.

Publication date :

1991

Journal title :

Journal of Molecular Biology

ISSN :

0022-2836

eISSN :

1089-8638

Publisher :

Academic Press, London, United Kingdom

Volume :

222

Issue :

Pages :

155-65

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 23 November 2009

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