Enhancement of nuclear receptor transcriptional signalling.

Renkawitz, Rainer; Kaltschmidt, Christian; Leers, Joerg; Martin, Bernd; Muller, Marc; Eggert, Martin

doi:10.1016/0960-0760(95)00222-7

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Article (Scientific journals)

Enhancement of nuclear receptor transcriptional signalling.

Renkawitz, Rainer; Kaltschmidt, Christian; Leers, Joerg et al.

1996 • In Journal of Steroid Biochemistry and Molecular Biology, 56 (1-6 Spec No), p. 39-45

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https://hdl.handle.net/2268/29019

DOI
10.1016/0960-0760(95)00222-7

PubMed
8603046

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Keywords :

Animals; CCAAT-Enhancer-Binding Proteins; Carcinoma, Hepatocellular/pathology; Carrier Proteins/isolation & purification/metabolism; DNA-Binding Proteins/physiology; Dexamethasone/pharmacology; Enzyme Induction/drug effects; Genes, Reporter; Liver Neoplasms/pathology; Mice; Mice, Transgenic; Neoplasm Proteins/biosynthesis/genetics; Nuclear Proteins/physiology; Oncogene Proteins v-erbA/physiology; Receptors, Glucocorticoid/drug effects/physiology; Receptors, Thyroid Hormone/physiology; Regulatory Sequences, Nucleic Acid; Signal Transduction/drug effects; Transcription Factors/physiology; Transcription, Genetic/drug effects; Tryptophan Oxygenase/biosynthesis/genetics; Tumor Cells, Cultured

Abstract :

[en] Glucocorticoids and thyroid hormones induce complex responses in about every mammalian tissue. These effects are mediated by the transcription factor function of the corresponding nuclear receptors, which in most cases achieve the observed regulatory strength in synergy with other factors. Here we describe the functional interaction of the glucocorticoid receptor (GR) with liver-specific transcription factors, the functional synergy of GR with the thyroid hormone receptor (TR), the synergizing sub-domains of the TR, and finally the direct interaction of the GR with other proteins.

Disciplines :

Genetics & genetic processes

Author, co-author :

Renkawitz, Rainer

Kaltschmidt, Christian

Leers, Joerg

Martin, Bernd

Muller, Marc ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire

Eggert, Martin

Language :

English

Title :

Enhancement of nuclear receptor transcriptional signalling.

Publication date :

1996

Journal title :

Journal of Steroid Biochemistry and Molecular Biology

ISSN :

0960-0760

eISSN :

1879-1220

Publisher :

Pergamon Press, Oxford, United Kingdom

Volume :

Issue :

1-6 Spec No

Pages :

39-45

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 23 November 2009

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