[en] Glucocorticoids and thyroid hormones induce complex responses in about every mammalian tissue. These effects are mediated by the transcription factor function of the corresponding nuclear receptors, which in most cases achieve the observed regulatory strength in synergy with other factors. Here we describe the functional interaction of the glucocorticoid receptor (GR) with liver-specific transcription factors, the functional synergy of GR with the thyroid hormone receptor (TR), the synergizing sub-domains of the TR, and finally the direct interaction of the GR with other proteins.
Disciplines :
Genetics & genetic processes
Author, co-author :
Renkawitz, Rainer
Kaltschmidt, Christian
Leers, Joerg
Martin, Bernd
Muller, Marc ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Eggert, Martin
Language :
English
Title :
Enhancement of nuclear receptor transcriptional signalling.
Publication date :
1996
Journal title :
Journal of Steroid Biochemistry and Molecular Biology
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