Brain basic fibroblast growth factor stimulates the release of plasminogen activators by newborn rat cultured astroglial cells

Rogister, Bernard; Leprince, Pierre; Pettmann, B.; Labourdette; Sensenbrenner, M.; Moonen, Gustave

doi:10.1016/0304-3940(88)90700-8

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Brain basic fibroblast growth factor stimulates the release of plasminogen activators by newborn rat cultured astroglial cells

Rogister, Bernard; Leprince, Pierre; Pettmann, B. et al.

1988 • In Neuroscience Letters, 91 (3), p. 321-326

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https://hdl.handle.net/2268/28652

DOI
10.1016/0304-3940(88)90700-8

PubMed
3185969

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Keywords :

Animals; Animals, Newborn; Astrocytes/drug effects/metabolism; Brain/metabolism; Cattle; Cells, Cultured; Culture Media/analysis; Fibroblast Growth Factors/pharmacology; Glioma; Plasminogen Activators/metabolism; Rats; Tumor Cells, Cultured/drug effects/metabolism

Abstract :

[en] Basic fibroblast growth factor (bFGF), a growth factor for many cell types including newborn rat astroglial cells, stimulates in a dose-dependent fashion the release of plasminogen activators (PAs) by these cells as measured by the fibrin-overlay method or the Coleman and Green's colorimetric assay. This effect of bFGF on PAs secretion (about 4.5-fold increase at 40 ng/ml bFGF) does not result from an aspecific stimulation of protein secretion by astrocytes and is only partly correlated with the mitogenic activity of bFGF. bFGF was also tested on two clonal glioma cell lines (C6 and LN18). Only one of those cell types (LN18) showed a stimulated PA release in the presence of bFGF. These data are discussed with respect to the putative roles of plasminogen activators in the developing nervous system.

Disciplines :

Anatomy (cytology, histology, embryology...) & physiology
Neurology

Author, co-author :

Rogister, Bernard ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine

Leprince, Pierre ; Université de Liège - ULiège > GIGA - Neurosciences

Pettmann, B.

Labourdette

Sensenbrenner, M.

Moonen, Gustave ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie

Language :

English

Title :

Brain basic fibroblast growth factor stimulates the release of plasminogen activators by newborn rat cultured astroglial cells

Publication date :

1988

Journal title :

Neuroscience Letters

ISSN :

0304-3940

eISSN :

1872-7972

Publisher :

Elsevier Scientific Publishers Ireland, Limerick, Ireland

Volume :

Issue :

Pages :

321-326

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Available on ORBi :

since 20 November 2009

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