Reference : Plasminogen activators in developing peripheral nervous system, cellular origin and m...
Scientific journals : Article
Human health sciences : Neurology
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
http://hdl.handle.net/2268/28651
Plasminogen activators in developing peripheral nervous system, cellular origin and mitogenic effect.
English
Baron-Van Evercooren, A. [> > > >]
Leprince, Pierre mailto [Université de Liège - ULiège > > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc. >]
Rogister, Bernard mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Lefebvre, Philippe mailto [Université de Liège - ULiège > > O.R.L. >]
Delree, P. [> > > >]
Selak, Ivan mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Moonen, Gustave mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
1987
Brain Research
Elsevier Science
433
1
101-8
Yes (verified by ORBi)
International
0006-8993
Amsterdam
The Netherlands
[en] Animals ; Animals, Newborn ; Cells, Cultured ; Ganglia, Spinal/drug effects/growth & development/metabolism ; Mitosis/drug effects ; Peripheral Nerves/drug effects/growth & development ; Plasminogen Activators/metabolism/pharmacology ; Rats ; Rats, Inbred Strains ; Schwann Cells/drug effects/metabolism ; Tissue Plasminogen Activator/metabolism/pharmacology ; Urokinase-Type Plasminogen Activator/metabolism/pharmacology
[en] Newborn rat dorsal root ganglia release two different plasminogen activators (PAs): the urokinase (UK) and the tissue (tPA) type. The former is secreted by neurons while the latter is secreted by Schwann cells. tPA release by Schwann cells is modulated by choleratoxin, a known mitogen for these cells. UK but not tPA stimulates in a dose-dependent fashion the proliferation of Schwann cells. This effect is observed in the absence of plasminogen, suggesting that the substrate for PAs in the developing nervous system is not plasminogen. Since UK is secreted by neurons, our data suggest a new mechanism for neuronal control of Schwann cell proliferation.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
http://hdl.handle.net/2268/28651
also: http://hdl.handle.net/2268/36078 ; http://hdl.handle.net/2268/94528
10.1016/0165-3806(87)90068-X

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