Plasminogen activators in developing peripheral nervous system, cellular origin and mitogenic effect.

Baron-Van Evercooren, A.; Leprince, Pierre; Rogister, Bernard; Lefebvre, Philippe; Delree, P.; Selak, Ivan; Moonen, Gustave

doi:10.1016/0165-3806(87)90068-X

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Plasminogen activators in developing peripheral nervous system, cellular origin and mitogenic effect.

Baron-Van Evercooren, A.; Leprince, Pierre; Rogister, Bernard et al.

1987 • In Brain Research, 433 (1), p. 101-8

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/28651

DOI
10.1016/0165-3806(87)90068-X

PubMed
3119159

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Keywords :

Animals; Animals, Newborn; Cells, Cultured; Ganglia, Spinal/drug effects/growth & development/metabolism; Mitosis/drug effects; Peripheral Nerves/drug effects/growth & development; Plasminogen Activators/metabolism/pharmacology; Rats; Rats, Inbred Strains; Schwann Cells/drug effects/metabolism; Tissue Plasminogen Activator/metabolism/pharmacology; Urokinase-Type Plasminogen Activator/metabolism/pharmacology

Abstract :

[en] Newborn rat dorsal root ganglia release two different plasminogen activators (PAs): the urokinase (UK) and the tissue (tPA) type. The former is secreted by neurons while the latter is secreted by Schwann cells. tPA release by Schwann cells is modulated by choleratoxin, a known mitogen for these cells. UK but not tPA stimulates in a dose-dependent fashion the proliferation of Schwann cells. This effect is observed in the absence of plasminogen, suggesting that the substrate for PAs in the developing nervous system is not plasminogen. Since UK is secreted by neurons, our data suggest a new mechanism for neuronal control of Schwann cell proliferation.

Disciplines :

Anatomy (cytology, histology, embryology...) & physiology
Neurology

Author, co-author :

Baron-Van Evercooren, A.

Leprince, Pierre ; Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc.

Rogister, Bernard ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine

Lefebvre, Philippe ; Université de Liège - ULiège > O.R.L.

Delree, P.

Selak, Ivan ; Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman

Moonen, Gustave ; Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman

Language :

English

Title :

Plasminogen activators in developing peripheral nervous system, cellular origin and mitogenic effect.

Publication date :

1987

Journal title :

Brain Research

ISSN :

0006-8993

eISSN :

1872-6240

Publisher :

Elsevier Science, Amsterdam, Netherlands

Volume :

433

Issue :

Pages :

101-8

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Available on ORBi :

since 20 November 2009

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