A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.

Hargreaves, K.; Dubner, R.; Brown, F.; Flores, C.; Joris, Jean

doi:10.1016/0304-3959(88)90026-7

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A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.

Hargreaves, K.; Dubner, R.; Brown, F. et al.

1988 • In Pain, 32 (1), p. 77-88

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/26794

DOI
10.1016/0304-3959(88)90026-7

PubMed
3340425

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Keywords :

Animals; Carrageenan; Hot Temperature/diagnostic use; Hyperalgesia/physiopathology; Hyperesthesia/physiopathology; Indomethacin/diagnostic use; Male; Morphine/diagnostic use; Pain/physiopathology; Pain Measurement/methods; Rats; Rats, Inbred Strains; Sensory Thresholds; Skin/innervation

Abstract :

[en] A method to measure cutaneous hyperalgesia to thermal stimulation in unrestrained animals is described. The testing paradigm uses an automated detection of the behavioral end-point; repeated testing does not contribute to the development of the observed hyperalgesia. Carrageenan-induced inflammation resulted in significantly shorter paw withdrawal latencies as compared to saline-treated paws and these latency changes corresponded to a decreased thermal nociceptive threshold. Both the thermal method and the Randall-Selitto mechanical method detected dose-related hyperalgesia and its blockade by either morphine or indomethacin. However, the thermal method showed greater bioassay sensitivity and allowed for the measurement of other behavioral parameters in addition to the nociceptive threshold.

Disciplines :

Anesthesia & intensive care

Author, co-author :

Hargreaves, K.

Dubner, R.

Brown, F.

Flores, C.

Joris, Jean ; Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation

Language :

English

Title :

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.

Publication date :

1988

Journal title :

Pain

ISSN :

0304-3959

eISSN :

1872-6623

Publisher :

Elsevier Science, Amsterdam, Netherlands

Volume :

Issue :

Pages :

77-88

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 27 October 2009

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