Chapter 10-Microfluidics in three key aspects of the drug-development process: biomarker discovery, preclinical studies and drug delivery systems

Nix, Cindy; Fillet, Marianne

doi:10.1016/B978-0-444-59432-7.00017-0

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Chapter 10-Microfluidics in three key aspects of the drug-development process: biomarker discovery, preclinical studies and drug delivery systems

Nix, Cindy; Fillet, Marianne

2022 • In Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-chip

Peer reviewed

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https://hdl.handle.net/2268/267690

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10.1016/B978-0-444-59432-7.00017-0

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Keywords :

Microfluidics; Pharmaceutical analysis; Drug development

Abstract :

[en] Drug development is an expensive and time-consuming process and many diseases still cannot be treated effectively by drugs currently available. In this context, microfluidics offer many benefits that may tackle current challenges of drug development. Indeed, microfluidic platforms have been recently developed to improve and accelerate all the steps in drug development, from the target discovery to the postmarketing quality control. This chapter will be focused on three aspects in drug development where microfluidic technology plays a key role: biomarker discovery, preclinical studies, including microsampling and organ-on-a-chip-devices, and drug delivery systems. For each section, a general overview is provided and several representative examples are described.© 2022 Elsevier B.V.

Research Center/Unit :

CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Nix, Cindy ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Fillet, Marianne ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Language :

English

Title :

Chapter 10-Microfluidics in three key aspects of the drug-development process: biomarker discovery, preclinical studies and drug delivery systems

Publication date :

2022

Main work title :

Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-chip

Publisher :

Elsevier

Pages :

275-295

Peer reviewed :

Peer reviewed

Available on ORBi :

since 31 January 2022

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