No full text
Article (Scientific journals)
Surgical management of amiodarone-associated thyrotoxicosis: too risky or too effective?
Hamoir, Etienne; Meurisse, Michel; Defechereux, Thierry et al.
1998In World Journal of Surgery, 22 (6), p. 537-42; discussion 542-3
Peer Reviewed verified by ORBi
 

Files


Full Text
No document available.

Send to



Details



Keywords :
Aged; Aged, 80 and over; Amiodarone/adverse effects; Anti-Arrhythmia Agents/adverse effects; Female; Humans; Male; Middle Aged; Thyroidectomy; Thyrotoxicosis/chemically induced/surgery; Treatment Outcome
Abstract :
[en] Amiodarone-associated thyrotoxicosis, often clinically mild and resolutive after amiodarone discontinuation or under medical therapy, is sometimes drug unresponsive and not uncommonly follows a dramatic, even fatal course. Therefore, we considered a surgical solution in 15 severely amiodarone-associated thyrotoxic patients. Twelve men and three women (mean age 68 years, range 50-84 years) underwent radical thyroidectomy for clinical and biologically proved amiodarone-associated thyrotoxicosis. In six surgery was the first-line therapeutic option. In the other nine thyroidectomy seemed unavoidable considering the unresponsiveness to medical therapy and rapid deterioration of the patients' clinical condition, with life-threatening cardiac failure in three. In every patient surgery was conducted without immediate or delayed complications. Total thyroidectomy proved uniformly, definitively, and rapidly effective in controlling thyrotoxicosis in all patients, with a spectacular reversal of cardiac failure in the three most critical cases. Surgery was beneficial to our 15 patients and undoubtedly life-saving in the three most worrying cases. These results suggest that thyroidectomy should be more liberally regarded as an interesting alternative to conventional, but unpredictably effective, medical therapies.
Disciplines :
Anesthesia & intensive care
Surgery
Author, co-author :
Hamoir, Etienne ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Meurisse, Michel ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Defechereux, Thierry ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Joris, Jean ;  Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
Vivario, Janine ;  Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique
Hennen, Georges ;  Centre Hospitalier Universitaire de Liège - CHU > Endocrinologie clinique
Language :
English
Title :
Surgical management of amiodarone-associated thyrotoxicosis: too risky or too effective?
Publication date :
1998
Journal title :
World Journal of Surgery
ISSN :
0364-2313
eISSN :
1432-2323
Publisher :
Springer Verlag, New York, United States - New York
Volume :
22
Issue :
6
Pages :
537-42; discussion 542-3
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 October 2009

Statistics


Number of views
60 (1 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
54
Scopus citations®
without self-citations
52

Bibliography


Similar publications



Contact ORBi