[en] The aim of this study was to determine the cardiac performance of conscious healthy dogs during stimulation with dobutamine. Eight healthy unsedated beagle dogs were used. Cardiac output was measured by the thermodilution technique and blood pressures by extravascular pressure transducers. Dobutamine challenge at a dosage ranging from 27.5 to 50 micrograms kg-1 min-1 induced a significant rise in cardiac power index (CPI), cardiac index (CI), stroke index (SI) and heart rate (HR) and a significant decrease in pulmonary vascular resistance (PVR) and systemic vascular resistance (SVR). The highest CPI was 2.05 times greater than its basal resting value. The CI was primarily responsible for this increase in CPI. The SI and HR contributed approximately 55 per cent and 45 per cent respectively of the maximal increase in CI.
Disciplines :
General & internal medicine
Author, co-author :
Mc Entee, Kathleen ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Sémiologie et clinique médicale des petits animaux
Clercx, Cécile ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Pathologie médicale des petits animaux
Pypendop, B.
Peeters, Dominique ; Université de Liège - ULiège > Clinique des petits animaux
Balligand, Marc ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Chirurgie et clinique chirurgicale des petits animaux
D'Orio, Vincenzo ; Université de Liège - ULiège > Département des sciences cliniques > Médecine d'urgence - bioch. et phys. hum. normales et path.
Henroteaux, Marc ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés
Language :
English
Title :
Cardiac Performance in Conscious Healthy Dogs During Dobutamine Infusion
Amory, H., McEntee, K., Linden, A., Desmecht, D., Beduin, J.-M., D'Orio, V., Lekeux, P., Comparison of the cardiac pumping capability and cardiac pumping reserve in double-muscled and conventional calves (1993) Canadian Journal of Physiology and Pharmacology, 71, pp. 946-951
Atkins, C.E., Curtis, M.B., McGuirk, S.M., Kittleson, M.D., Sato, T., Snyder, P.S., The use of m-mode echocardiography in determining cardiac output in dogs with normal, low and high output states: Comparison to thermodilution method (1992) Veterinary Radiology and Ultrasound, 33, pp. 297-304
Bednarski, R.M., Muir, W.W., Arrhythmogenicity of dopamine, dobutamine, and epinephrine in thiamylal-halothane anesthetized dogs (1983) American Journal of Veterinary Research, 44, pp. 2341-2343
Berthe, C., Pierard, L., Hiernaux, M., Trotteur, G., Lempereur, G., Carlier, J., Kulbertus, H.E., Predicting the extent and location of coronary artery disease in acute myocardial infarction by echocardiography during dobutamine infusion (1986) American Journal of Cardiology, 58, pp. 1167-1172
Bonagura, J.D., Kirk, R.W., (1995) Kirk's Current Veterinary Therapy, p. 775. , Eds J. D Bonagura and R. W Kirk Philadelphia, USA, W B. Saunders
Calvert, C.A., Update: Canine dilated cardiomyopathy (1992) Current Veterinary Therapy, 11, pp. 773-779. , Eds R. W. Kirk and J. D Bonagura. Philadelphia, W B Saunders
Cigarroa, C.G., De Filippil, C.R., Brickner, M.E., Alvarez, L.G., Wai, M.A., Graiburn, P.A., Dobutamine stress echocardiography identifies hibernating myocardium and predicts recovery of left ventricular function after coronary revascularization (1993) Circulation, 88, pp. 430-436
Cissik, J.H., Ehler, W.J., Hankins, G.D., Hauth, J.C., Pierson, W.A., Determination of cardiac output and other reference physiology parameters in lightly anesthetized dogs (1987) Comparative Biochemistry and Physiology, 88 A, pp. 89-93
Darovic, G.O., (1987) Hemodynamic Monitoring. Invasive and Noninvasive Clinical Applications, p. 123. , Ed D Kay. Philadelphia, W. B. Saunders
Eichelberger, J., Schwarz, K., Black, E.R., Green, R.M., Ouriel, K., Predictive value of dobutamine echocardiography just before noncardiac vascular surgery (1993) American Journal of Cardiology, 72, pp. 602-607
Farver, T.B., Haskins, S.C., Patz, J.D., Cardiopulmonary effects of acepromazine and of the subsequent administration of ketamine in the dog (1986) American Journal of Veterinary Research, 47, pp. 631-635
Franciosa, J.A., Park, M., Levine, T.B., Lack of correlation between exercise capacity and indexes of resting left ventricular performance in heart failure (1981) American Journal of Cardiology, 47, pp. 33-39
Freeman, M.L., Palac, R., Mason, J., Barnes, W.E., Eastman, G., Virupannavar, S., Loeb, H.S., Kaplan, E., A comparison of dobutamine infusion and supine bicycle exercise for radionuclide cardiac stress testing (1984) Clinical Nuclear Medicine, 9, pp. 251-255
Haidet, G.C., Musch, T.I., Ordway, G.A., Mltcell, J.H., Exercise, dobutamine and combined atropine, norepinephrine and epinephrine compared (1985) Journal of Applied Physiology, 58, pp. 2047-2053
Haskins, S.C., Patz, J.D., Farver, T.B., Xylazine and xylazine-ketamine in dogs (1986) American Journal of Veterinary Research, 47, pp. 636-641
Hinds, J.E., Hawthorne, E.W., Comparative cardiac dynamic effects of dobutamine and isoproterenol in conscious instrumented dogs American (1975) Journal of Cardiology, 36, pp. 894-901
Hoffmann, R., Lethen, H., Kleinhans, E., Flachskampf, F.A., Hanrath, R., Comparative evaluation of bicycle and dobutamine stress echocardiography with perfusion scintigraphy and bicycle electrocardiogram for identification of coronary artery disease (1993) American Journal of Cardiology, 72, pp. 555-559
Jewitt, D., Mitchell, A., Birkhead, J., Dollery, C., Clinical cardiovascular pharmacology of dobutamine, a selective inotropic cathecholamine (1974) Lancet, 2, pp. 363-367
Kanda, H., Dobutamine infusion test for predicting the postoperative recovery of left ventricular function in patients with chronic aortic regurgitation (1989) Journal of the Japanese Association of Thoracic Surgery, 37, pp. 2281-2289
Klewer, S.E., Goldberg, S.J., Donnerstein, R.L., Berg, R.A., Hutter Jr., J.J., Dobutamine stress echocardiography: A sensitive indicator of diminished myocardial function in asymptomatic doxorubicin-treated long-term survivors of childhood cancer (1992) Journal of the American College of Cardiology, 19, pp. 394-401
Mannering, D., Cripps, T., Leech, G., Mehta, N., Valantine, H., Gilmour, S., Bennett, E.D., The dobutamine stress test as an alternative to exercise stress testing after acute myocardial infarction (1988) British Heart Journal, 59, pp. 521-526
Mariotti, E., Agostini, A., Angelucci, E., Cesaroni, P., Lucarelli, G., Sgarbi, E., Cardiac study by dobutamine stress echocardiography in thalassemic patients (1993) Bone Marrow Transplantation, 12 (1 SUPPL.), pp. 14-15
Mertes, H., Sawada, S.G., Ryan, T., Segar, D.S., Kovacs, R., Foltz, J., Feigenbaum, H., Symptoms, adverse effects and complications associated with dobutamine stress echocardiography. Experience in 1118 patients (1993) Circulation, 88, pp. 15-19
Miller, M.S., Tilley, L.P., (1995) Manual of Canine and Feline Cardiology. 2nd Edn, , Philadelphia, W. B. Saunders
Sawada, S.G., Segar, D.S., Ryan, T., Brown, S., Dohan, A.M., Williams, R., Fineberg, N.S., Feigenbaum, H., Echocardiographic detection of coronary artery disease during dobutamine infusion (1991) Circulation, 83, pp. 1605-1614
Swanson, C.R., Muir, W.W., Bednarski, R.M., Skarda, R.T., Hubbell, J.A.E., Hemodynamic responses in halothane-anesthetized horses given infusions of dopamine or dobutamine (1985) American Journal of Veterinary Research, 46, pp. 365-370
Tan, L.B., Cardiac pumping capacity and prognosis in heart failure (1986) Lancet, pp. 1360-1363
Tan, L.B., Clinical and research implications of new concepts in the assessment of cardiac pumping performance in heart failure (1987) Cardiovascular Research, 21, pp. 615-622
Tan, L.B., Bain, R.J.I., Littler, W.A., Assessing cardiac pumping capability by exercise testing and inotropic stimulation (1989) British Heart Journal, 62, pp. 20-25
Taylor, C.R., Karas, R.H., Weibel, E.R., Hoppeler, H., Adaptative variation in the mammalian respiratory system in relation to energetic demand: 2. Reaching the limits to oxygen flow (1987) Respiration Physiology, 69, pp. 7-26
Tuttle, R.R., Mills, J., Dobutamine. Development of a new cathecholamine to selectively increase cardiac contractility (1975) Circulation Research, 36, pp. 185-196
Vatner, S.F., McRitchie, R.J., Braunwald, E., Effects of dobutamine on left ventricular performance, coronary dynamics, and distribution of cardiac output in conscious dogs (1974) Journal of Clinical Investigation, 53, pp. 1265-1273
Wackers, F.J., Which pharmacological stress is optimal? a technique-dependent choice (1993) Circulation, 87, pp. 646-648
Willens, H.J., Blevins, R.D., Wrisley, D., Antoniscen, D., Reinstein, D., Rubenfire, M., The prognostic value of functional capacity in patients with mild to moderate heart failure (1987) American Heart Journal, 114, pp. 377-382