No document available.
Abstract :
[en] In various species, including human, the onset of puberty is characterized by an increase of GnRH pulsatility and subsequently hypophyseal LH secretion. The hypothalamus including GnRH neurons is a leading structure in the hypothalamo-pituitary-gonadal axis. While variations in frequency are essential for the onset of puberty, the increase in GnRH and LH pulse amplitude is very important for the preovulatory surge, a critical time for female reproductive function. The aim of this review is to describe the mechanisms involved in the GnRH pulse generator and the contribution of internal and external signals accounting for the acceleration of GnRH pulse generator and therefore the onset of puberty.
Scopus citations®
without self-citations
0