[en] A seven-year-old, female golden retriever was referred for a paroxysmal, chronic cough and dyspnea, dysphagia, facial pruritus, anterior uveitis, and deteriorating general condition. A severe, mixed interstitial and alveolar pattern, with poorly defined amorphous lesions, was seen on thoracic radiographs. Multiple, whitish nodules disseminated on the hyperemic respiratory mucosa were noted on bronchoscopy. Escherichia coli and Aspergillus fumigatus were cultured from the bronchoalveolar lavage. Granulomatous lesions in numerous organs were identified during necropsy, and Aspergillus fumigatus and Candida spp. were cultured from lung and kidney tissues. Microscopic granulomatous lesions were compatible with mycotic infection; however fungal organisms were not observed.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Clercx, Cécile ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Pathologie médicale des petits animaux
Mc Entee, Kathleen ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Sémiologie et clinique médicale des petits animaux
Snaps, Frédéric ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Imagerie médicale
Jacquinet, E.
Coignoul, Freddy ; Université de Liège - ULiège > Département de morphologie et pathologie > Pathologie générale et autopsies
Language :
English
Title :
Bronchopulmonary and Disseminated Granulomatous Disease Associated with Aspergillus Fumigatus and Candida Species Infection in a Golden Retriever
Publication date :
1996
Journal title :
Journal of the American Animal Hospital Association
ISSN :
0587-2871
eISSN :
1547-3317
Publisher :
American Animal Hospital Association, United States - Colorado
Goldner RD, Adams DO. The structure of mononuclear phagocytes differentiating in vivo III. The effect of participate foreign substances Am J Pathol 1977;89:335
Cheville NF. Cells of inflammation and immunity. In: Cheville NF, ed. Ultrastructural pathology. An introduction to interpretation. 1st ed. Ames, Iowa: Iowa State Univ Press, 1994.460.
Khoo JK, Sugai JK, Leong TK. Disseminated aspergillosis: case report and review of world literature. Am J Clin Pathol 1975;45:697-703.
Day MJ. Canine disseminated aspergillosis. In: Greene CE, ed Infectious diseases of the dog and cat Philadelphia: WB Saunders, 1990:719-22.
Greene CE, Chandler FW. Candidiasis In: Greene CE, ed. Infectious diseases of the dog and cat Philadelphia: WB Saunders, 1990:723-7.
Barrett RE, Hoffer RE, Schultz RD. Treatment and immunological evaluation of three cases of canine aspergillosis. J Am Anim Hosp Assoc 1977; 13:328-40.
Hughes WT Systemic candidiasis: a study of 109 fatal cases. Pediatr Infect Dis 1982;1:11-8
Harvey CE, O'Brian JA. Nasal aspergillosis/penicilliosis In. Kirk RW, ed. Current veterinary therapy VIII Philadelphia: WB Saunders, 1983:236-41
Sharp NJH. Aspergillosis and penicilliosis. In: Greene CE, ed. Infectious diseases of the dog and cat Philadelphia: WB Saunders, 1990:714-9
Neer TM. Disseminated aspergillosis. Comp Sm Anim 1988;10:465-72
Day MJ, Penhale WJ, Eger CE, et al Disseminated aspergillosis in dogs. Austr Vet J 1986;63.55-9.
Kabay MJ, Robinson WF, Huxtable CRR, McAleer R. The pathology of disseminated Aspergillus terreus in dogs. Vet Pathol 1985;22:540-7
Jang SS, Dor TE, Biberstein EL, Wong A. Aspergillus deflectus in four dogs J Med Vet Mycol 1986;24.95
Day MJ, Eger CE, Shaw SE, Penhale WJ. Immunologic study of systemic aspergillosis in German shepherd dogs. Vet Immunol Immunopathol 1985;9:335-47.
Day MJ, Penhale WJ. Humoral immunity in disseminated Aspergillus terreus infection in the dog. Vet Microbiology 1988;16:283-94.
Zeidner N, Ruark S Ketaconazole treatment of primary aspergillosis pneumonia in a dog. Mod Vet Pract 1987,68:300-2.
Southard C. Bronchopulmonary aspergillosis in a dog J Am Vet Med Assoc 1987,190:875-7.
Guerin SR, Walker MC, Kelly DF. Cavitating mycotic pulmonary infection in a German shepherd dog. J Sm Anim Pract 1993;34:36-9
Ohshima KI, Naito Y, Seimiya Y. Mycotic bronchitis in a dog affected with distemper. Jap J Vet Sci 1979;41 83-7.
Poonacha JB, Smith HL. Naturally occurring Tyzzer's disease as a complication of distemper and mycotic pneumonia in a dog. J Am Vet Med Assoc 1976;169:419-20
Issoun TT. Disseminated aspergillosis in a dog. J Nigerian Vet Med Assoc 1975;4 45-8
Wood GL, Hirsch DC, Selcer RR, Rinaldi MG, Boorman GA. Disseminated aspergillosis in a dog J Am Vet Med Assoc 1978,172:704-7.
Pagani A, Spalla F, Ferrari FA, et al. Defective Aspergillus killing by neutrophil leucocytes in a case of systemic aspergillosis. Clin Exp Immunol 1981;43:201-7
Fietta A, Sacchi F, Mangiarotti P, et al. Defective phagocyte Aspergillus killing associated with recurrent pulmonary Aspergillus infections. Infection 1984;12:10-4.
Ehrensaft DV, Epstein RB, Sarpel S, Andersen BR. Disseminated candidiasis in leucopenic dogs Proc Soc Exp Biol Med 1979;160:6-10.
Andersonn PG, Pidgeon G Candidiasis in a dog with parvoviral enteritis J Am Anim Hosp Assoc 1988;23:27-30.
Holoymoen JL, Bkerkas I Olberg IH Vea Mork A Disseminated candidiasis (moniliasis) in a dog. A case report Nord Vet Med 1982,34:362-7.
Weitkamp RA. Aspergilloma in two dogs. J Am Anim Hosp Assoc 1982;18:503-6
Mullaney TD, Levin S, Indrier RJ. Disseminated aspergillosis in a dog. J Am Vet Med Assoc 1983;182:516-8.
Marks DL Systemic aspergillosis in a dog. Canine Pract 1983;10:49-52.
Oxenford CJ, Middleton DJ. Osteomyelitis and arthritis associated with Aspergillus fumigatus in a dog. Austr Vet J 1986;63:59
Gelati KN, Chrisman CL, Samuelson DA, Shell LG, Buergelt CD. Ocular and systemic aspergillosis in a dog. J Am Anim Hosp Assoc 1991;27:427-31.
Dallman MJ, Dew TL, Tobias L, Doss R. Disseminated aspergillosis in a dog with diskospondylitis and neurologic deficits. J Am Vet Med Assoc 1992;200 511-3.
Pastor J, Pumarola M, Cuenca R, Lavin S. Systemic aspergillosis in a dog. Vet Rec 1993;132:412-3.
Kaufman AC, Greene CE, Selcer BA, Styles ME, Mahaffey EA. Systemic aspergillosis in a dog and treatment with hamycin. J Am Anim Hosp Assoc 1994;30:132-6.
Butterworth SJ, Barr FJ, Pearson GR, Day MJ. Multiple discospondylitis associated with Aspergillus species infection in a dog. Vet Rec 1995,136:38-41.
Suter PF, Lord PF Thoracic radiography. In: Suter PF, ed. A text atlas of thoracic diseases of the dog and cat. Wettswil, Switzerland. 1984:616.
Peet RL, Robertson LD. Suspected aspergillosis in a dog. Austral Vet J 1976; 52.539-40.
