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Poster (Scientific congresses and symposiums)
Comparative sequence analysis of the Insulin-IGF2 region harbouring a major QTL for muscle development in the pig
Van Laere, Anne-Sophie; Amarger, Valérie; Andersson, Leif
200228th Conference of the International Society of Animal Genetics, Göttingen, Germany
 

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Keywords :
QTL; IGF2; pig
Abstract :
[en] We and others have identified a paternally expressed Quantitative Trait Locus (QTL) primarily affecting muscle development at the distal tip of pig chromosome 2p. IGF2 (Insulin-like Growth Factor 2) was identified as the major candidate gene due to its perfect co-localisation with the QTL, its paternal imprinting, and its important role in prenatal development in mammals. This QTL is segregating in our Wild Boar/Large White intercross and previous studies did not reveal any sequence difference in the IGF2 coding sequence. Thus, we assume that the QTL may be due to one or more regulatory mutations. We have now determined 32 kb contiguous genomic sequence containing the Insulin-IGF2 region. This region contains a very high GC content, many CpG islands and very few interspersed repeats. A comparative sequence analysis with the homologous region in humans and mouse revealed that all coding sequences are well conserved between species but also that a large proportion of the non-coding sequence in this region is surprisingly well conserved between species. The results will facilitate the further characterization of this important QTL in the pig and we are currently doing comparative sequence analysis of chromosomes with known QTL status in the search for causative mutation(s).
Disciplines :
Genetics & genetic processes
Author, co-author :
Van Laere, Anne-Sophie  ;  Swedish University of Agricultural Sciences(SLU) > Department of Animal Breeding andGenetics
Amarger, Valérie;  Swedish University of Agricultural Sciences(SLU) > Department of Animal Breeding andGenetics
Andersson, Leif;  Swedish University of Agricultural Sciences(SLU) > Department of Animal Breeding andGenetics
Language :
English
Title :
Comparative sequence analysis of the Insulin-IGF2 region harbouring a major QTL for muscle development in the pig
Publication date :
August 2002
Event name :
28th Conference of the International Society of Animal Genetics, Göttingen, Germany
Event date :
11/08/2002 - 15/08/2002
Audience :
International
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since 03 September 2020

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