[en] Spaceflight severely impacts the human body. Moreover, little is known about how gravity and gravitational alterations affect the human brain. Here, we aimed at measuring the effects of acute exposure to gravity transitions. We exposed 28 naïve participants to repetitive alterations between normal, hyper- and microgravity induced by a parabolic flight (PF) and measured functional MRI connectivity changes. Scans were acquired before and after the PF. To mitigate motion sickness, PF participants received scopolamine prior to PF. To account for the scopolamine, 12 non-PF controls were scanned prior to and after scopolamine injection. Changes in functional connectivity were explored with the Intrinsic Connectivity Contrast (ICC). Seed-based analysis on the regions exhibiting localized changes was subsequently performed to understand the networks associated with the identified nodes. We found that the PF group was characterized by lower ICC scores in the right temporo-parietal junction (rTPJ), an area involved in multisensory integration and spatial tasks. The encompassed network revealed PF-related decreases in within- and inter-hemispheric anticorrelations between the rTPJ and the supramarginal gyri, indicating both altered vestibular and self-related functions. Our findings shed light how the brain copes with gravity transitions, on gravity internalization and are relevant for the understanding of bodily self-consciousness [1].
Disciplines :
Neurology
Author, co-author :
Van Ombergen, A.; Antwerp University Research Centre for Equilibrium and Aerospace (AUREA), University of Antwerp, Belgium
Wuyts, F. L.; Antwerp University Research Centre for Equilibrium and Aerospace (AUREA), University of Antwerp, Belgium
Jeurissen, B.; Imec/Vision Lab, Department of Physics, University of Antwerp, Belgium
Sijbers, J.; Imec/Vision Lab, Department of Physics, University of Antwerp, Belgium
Vanhevel, F.; Department of Radiology, Antwerp University Hospital, University of Antwerp, Belgium
Jillings, Steven ; Antwerp University Research Centre for Equilibrium and Aerospace (AUREA), University of Antwerp, Belgium
Parizel, P. M.; Department of Radiology, Antwerp University Hospital, University of Antwerp, Belgium
Sunaert, S.; KU Leuven - University of Leuven, Department of Imaging and Pathology, Translational MRI, Leuven, Belgium
Van De Heyning, P. H.
Dousset, V.; University of Bordeaux, CHU de Bordeaux, INSERM Magendie, Bordeaux, France
Laureys, Steven ; Université de Liège - ULiège > Consciousness-Coma Science Group
Demertzi, Athina ; Université de Liège - ULiège > Consciousness-Physiology of Cognition
Language :
English
Title :
Altered intrinsic functional brain connectivity after first-time exposure to short-term gravitational alterations induced by parabolic flight.
Publication date :
2018
Event name :
69th International Astronautical Congress: #InvolvingEveryone, IAC 2018
Event date :
1 October 2018 through 5 October 2018
Audience :
International
Main work title :
Proceedings of the 69th International Astronautical Congress
Publisher :
International Astronautical Federation, IAF
Collection name :
Proceedings of the International Astronautical Congress, IAC (issn 00741795)
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