[en] This study was carried out in order to categorize visual signs of peritoneal cacirnomatosis after mesh implantation following resection and/or cytoreduction. Using the murine model of ovarian-type peritoneal cancer (PC) which is induced by intraperitoneal injection of ID8 – Luc ovarian cancer cells in immunocompetent C57BL/6 mice in the presence or the absence of intraabdominal prostheses (Surgimend or Ventralex) shows that these prostheses promote pro-tumor development assessed by bioluminescence. The biosynthetic mesh (Ventralex) decreases the survival of the animals whatever the experimental time of prosthesis implantation. Moreover, Ventralex is completely invaded by tumor nodules. In contrast, a vascular network was well visible naked eye on the biological mesh (Surgimend). However, it seems to be devoid of tumor nodules. Using scanning electron microscopy (SEM) allowed us to deny this macroscopic observation. In addition, these SEM observations revealed a probable epithelial-mesenchymal (TEM) transition. In other hand, the in vitro ID8-Luc cell interaction with both protheses assessed by SEM showed similar modified cell phenotype. Using such murine PC model, the safety of this pre-clinical prosthesis implantation strategy shows us that our incompetence to reduce tumor growth and to obtain better tumor control after resection or cytoreduction. The results obtained with prostheses encourage us not to recommend their use in case of intraabdominal pathology (hernia, evisceration, carcinosis). This should prompt providers to change the structure and composition of intra-abdominal prostheses to improve survival and prevent tumor development.
