Reference : Beta blockers and the central nervous system.
Scientific journals : Article
Human health sciences : Neurology
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/24655
Beta blockers and the central nervous system.
English
Schoenen, Jean mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
1986
Cephalalgia
Blackwell Science
6 Suppl 5
47-54
Yes (verified by ORBi)
International
0333-1024
1468-2982
Osney Mead Oxford
United Kingdom
[en] Adrenergic beta-Antagonists/blood/therapeutic use ; Animals ; Blood-Brain Barrier/drug effects ; Brain/drug effects ; Cerebral Arteries/innervation ; Cerebrovascular Circulation/drug effects ; Contingent Negative Variation/drug effects ; Dose-Response Relationship, Drug ; Humans ; Migraine Disorders/drug therapy ; Psychomotor Performance/drug effects ; Reaction Time/drug effects ; Receptors, Adrenergic, beta/drug effects
[en] The exact mechanism of action of beta blockers in migraine remains undetermined. An effect on the central nervous system (CNS) might be a factor. The evidence from the literature indicates that the anatomical and chemical targets for these drugs are present in the mammalian brain, that they readily penetrate the brain, and that they may modify CNS functions. The present study shows that psychomotor tests and contingent negative variation (CNV), an event related slow cerebral potential, both of which are abnormal in untreated migraineurs, tend to normalize after treatment with the beta blocker metoprolol. Moreover, a strong positive correlation was found between the amplitude of CNV and the clinical efficacy of beta blockers in migraineurs. One might hypothesize that a hyperactive central catecholaminergic state in migraine might be the common denominator between reduced performance on psychomotor testing and enhanced CNV. It remains to be determined whether this is due to hyperactivity of catecholaminergic neurons or to hypersensitivity of catecholamine receptors.
http://hdl.handle.net/2268/24655

There is no file associated with this reference.

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.