Reference : Androgen-dependent vasopressinergic neurons are involved in social recognition in rats.
Scientific journals : Article
Human health sciences : Neurology
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/24615
Androgen-dependent vasopressinergic neurons are involved in social recognition in rats.
English
Bluthe, R. M. [> > > >]
Schoenen, Jean mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
Dantzer, R. [> > > >]
1990
Brain Research
Elsevier Science
519
1-2
150-7
Yes (verified by ORBi)
International
0006-8993
Amsterdam
The Netherlands
[en] 2-Amino-5-phosphonovalerate/pharmacology ; Animals ; Arginine Vasopressin/analogs & derivatives/pharmacology ; Brain/cytology/drug effects/physiology ; Male ; Neurons/physiology ; Orchiectomy ; Rats ; Rats, Inbred Strains ; Reference Values ; Serotonin/analysis ; Social Behavior ; Testosterone/pharmacology ; Vasopressins/analysis/antagonists & inhibitors
[en] Socal recognition of juvenile conspecifics by adult male rats has been shown to be modulated by vasopressin. Because part of the extrahypothalamic vasopressinergic innervation of the brain is androgen-dependent, the present experiments were undertaken to assess possible interactions between androgens and vasopressin in social recognition. Castrated male rats displayed a temporary disruption of social recognition when they were tested 1 week after surgery. There was no impairment, however, when they were tested every other day following surgery. The peripheral injection of a vasopressor antagonist of vasopressin, dPTyr(Me)AVP (30 micrograms/kg) impaired social recognition in normal male rats but was ineffective in castrated ones. This was not due to an effect of castration on the basic pharmacological properties of dPTyr(Me)AVP since the antagonist peptide was still able to block the facilitating effects of vasopressin on social recognition in castrated male rats. Implantation of a testosterone-filled capsule in castrated male rats restored sensitivity of social recognition to the action of the vasopressin antagonist. These results suggest that androgen-dependent vasopressinergic neurons are physiologically involved in the modulation of social recognition in male rats.
http://hdl.handle.net/2268/24615
10.1016/0006-8993(90)90073-K

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