Reference : Contingent negative variation: methods and potential interest in headache.
Scientific journals : Article
Human health sciences : Neurology
Social & behavioral sciences, psychology : Neurosciences & behavior
Contingent negative variation: methods and potential interest in headache.
Schoenen, Jean mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
Timsit-Berthier, M. [> > > >]
Cephalalgia : An International Journal of Headache
Blackwell Science
Yes (verified by ORBi)
Osney Mead Oxford
United Kingdom
[en] Acoustic Stimulation ; Contingent Negative Variation/physiology ; Electroencephalography ; Headache/physiopathology ; Humans ; Photic Stimulation ; Sensitivity and Specificity ; Time Factors
[en] Contingent negative variation (CNV) is an event-related slow cerebral potential which has been found abnormal in migraine. Its methodology is described. Contrary to other neurophysiological techniques, CNV needs special equipment and expertise. On average, CNV amplitude is increased and its habituation is lacking in migraine without aura between attacks, but not in migraine with aura. The sensitivity of CNV as a diagnostic tool is low, but its specificity is high. CNV amplitude normalizes after treatment with beta-blockers. The CNV abnormalities in migraine might be due to hyperreactivity of central catecholaminergic pathways.

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