Reference : High-Dose Riboflavin as a Prophylactic Treatment of Migraine: Results of an Open Pilo...
Scientific journals : Article
Human health sciences : Neurology
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/24581
High-Dose Riboflavin as a Prophylactic Treatment of Migraine: Results of an Open Pilot Study
English
Schoenen, Jean mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie]
Lenaerts, M. [> >]
Bastings, E. [> > > >]
Oct-1994
Cephalalgia
Blackwell Science
14
5
328-9
Yes (verified by ORBi)
International
0333-1024
[en] If the brain of migraineurs is characterized between attacks by a reduction of mitochondrial phosphorylation potential, riboflavin, which has the potential of increasing mitochondrial energy efficiency, might have prophylactic effects in migraine. In this preliminary open pilot study, 49 patients suffering from migraine (45 without aura, 4 with aura) were treated with 400 mg of riboflavin as a single oral dose for at least 3 months. Twenty-three patients received in addition 75 mg of aspirin. Mean global improvement after therapy was 68.2% and there was no difference between the two groups of patients. With the exception of one patient in the riboflavin plus aspirin group who withdrew because of gastric intolerance, no drug-related side effects were reported. High-dose riboflavin could thus be an effective, low-cost prophylactic treatment of migraine devoid of short-term side effects. A placebo-controlled trial of its efficacy seems worthwhile.
http://hdl.handle.net/2268/24581
10.1046/j.1468-2982.1994.1405328.x

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