Reference : The effectiveness of combined oral lysine acetylsalicylate and metoclopramide compare...
Scientific journals : Article
Human health sciences : Neurology
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/24571
The effectiveness of combined oral lysine acetylsalicylate and metoclopramide compared with oral sumatriptan for migraine.
English
Tfelt-Hansen, P. [> > > >]
Henry, P. [> >]
Mulder, L. J. [> > > >]
Scheldewaert, R. G. [> > > >]
Schoenen, Jean mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
Chazot, G. [> > > >]
1995
Lancet
Lancet Publishing Group
346
8980
923-6
Yes (verified by ORBi)
International
0140-6736
1474-547X
London
United Kingdom
[en] Administration, Oral ; Adolescent ; Adult ; Analgesics/economics/therapeutic use ; Aspirin/analogs & derivatives/economics/therapeutic use ; Dopamine Antagonists/economics/therapeutic use ; Double-Blind Method ; Drug Costs ; Drug Therapy, Combination ; Female ; Humans ; Lysine/analogs & derivatives/economics/therapeutic use ; Male ; Metoclopramide/economics/therapeutic use ; Middle Aged ; Migraine Disorders/drug therapy ; Serotonin Agonists/adverse effects/economics/therapeutic use ; Sumatriptan/adverse effects/economics/therapeutic use
[en] Aspirin is commonly used to treat migraine attacks, although sumatriptan, a much more expensive treatment, is also effective. We compared a combination of lysine acetylsalicylate (equivalent to 900 mg aspirin) and 10 mg metoclopramide (LAS+MTC) with oral sumatriptan (100 mg) and placebo in 421 patients with migraine. LAS+MTC was as effective as sumatriptan with a decrease of headache from severe or moderate to mild or none of 57% and 53%, respectively, for the first migraine attack treated. Both treatments were better than placebo (success rate 24%, p < 0.0001). LAS+MTC was significantly more effective in the treatment of nausea than sumatriptan (p < 0.0001) and was better tolerated (adverse events in 18% and 28%, respectively, p < 0.05). LAS+MTC is as effective as sumatriptan in the treatment of migraine attacks. It is also much cheaper.
http://hdl.handle.net/2268/24571
10.1016/S0140-6736(95)91554-0

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