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Keywords :
Administration, Oral; Adolescent; Adult; Analgesics/economics/therapeutic use; Aspirin/analogs & derivatives/economics/therapeutic use; Dopamine Antagonists/economics/therapeutic use; Double-Blind Method; Drug Costs; Drug Therapy, Combination; Female; Humans; Lysine/analogs & derivatives/economics/therapeutic use; Male; Metoclopramide/economics/therapeutic use; Middle Aged; Migraine Disorders/drug therapy; Serotonin Agonists/adverse effects/economics/therapeutic use; Sumatriptan/adverse effects/economics/therapeutic use
Abstract :
[en] Aspirin is commonly used to treat migraine attacks, although sumatriptan, a much more expensive treatment, is also effective. We compared a combination of lysine acetylsalicylate (equivalent to 900 mg aspirin) and 10 mg metoclopramide (LAS+MTC) with oral sumatriptan (100 mg) and placebo in 421 patients with migraine. LAS+MTC was as effective as sumatriptan with a decrease of headache from severe or moderate to mild or none of 57% and 53%, respectively, for the first migraine attack treated. Both treatments were better than placebo (success rate 24%, p < 0.0001). LAS+MTC was significantly more effective in the treatment of nausea than sumatriptan (p < 0.0001) and was better tolerated (adverse events in 18% and 28%, respectively, p < 0.05). LAS+MTC is as effective as sumatriptan in the treatment of migraine attacks. It is also much cheaper.
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