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Unpublished conference/Abstract (Scientific congresses and symposiums)
Wildebeest-derived malignant catarrhal fever: a peripheral T cell lymphoproliferative disease caused by gammaherpesvirus latency
Dewals, Benjamin G
201742nd International herpesvirus Workshop
 

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Abstract :
[en] Wildebeests carry asymptomatically alcelaphine herpesvirus 1 (AlHV-1), a gammaherpesvirus inducing malignant catarrhal fever (MCF) to several ruminant species (including cattle). This acute and lethal lymphoproliferative disease occurs after a prolonged asymptomatic incubation period following transmission. MCF has a significant socio-economical impact in regions where wildebeest inhabit and there is a strong need for affordable, safe and efficacious vaccine. Here, I will present the recent advances we have made on our understanding of the pathogenesis of this disease, from the generation of an AlHV-1 BAC clone to the demonstration that viral episomal maintenance by the latency-associated nuclear antigen-homolog (aLANA) is essential for inducing MCF. Based on these findings, a model can be proposed where latency-associated sudden and uncontrolled proliferation of activated cytotoxic CD8+ T cells in the periphery leads to MCF development. These findings will be presented in the light of recent unpublished findings and in the prospect of vaccine development.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Dewals, Benjamin G  ;  Université de Liège - ULiège > Immunologie et vaccinologie
Language :
English
Title :
Wildebeest-derived malignant catarrhal fever: a peripheral T cell lymphoproliferative disease caused by gammaherpesvirus latency
Publication date :
2017
Event name :
42nd International herpesvirus Workshop
Event place :
Ghent, Belgium
Event date :
29 July to 3 August 2017
By request :
Yes
Audience :
International
Available on ORBi :
since 13 January 2020

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