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Helminth-induced interleukin 4 expands bystander memory T cells for early control of viral infection
Dewals, Benjamin G
2019Seventh annual meeting of the Belgian Society for Virology
 

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Abstract :
[en] Infection with parasitic helminths can imprint the immune system to modulate bystander inflammatory processes. Bystander or virtual memory CD8+ T cells (TVM) are non-conventional T cells displaying memory properties that can be generated through responsiveness to interleukin (IL)-4. However, it is not clear if helminth-induced type 2 immunity functionally affects the TVMcompartment. Here, we show that helminths expand CD44hiCD62LhiCXCR3hiCD49dlo TVM cells through direct IL-4 signaling in CD8+ T cells. Importantly, helminth-mediated conditioning of TVMcells provided enhanced control of acute respiratory infection with the murid gammaherpesvirus 4 (MuHV-4). This enhanced control of MuHV-4 infection could further be explained by an increase in antigen-specific CD8+ T cell effector responses in the lung and was directly dependent on IL-4 signaling. These results demonstrate that IL-4 during helminth infection can non-specifically condition CD8+ T cells, leading to a subsequently raised antigen-specific CD8+ T cell activation that enhances control of viral infection.
Disciplines :
Immunology & infectious disease
Author, co-author :
Dewals, Benjamin G  ;  Université de Liège - ULiège > Immunologie et vaccinologie
Language :
English
Title :
Helminth-induced interleukin 4 expands bystander memory T cells for early control of viral infection
Publication date :
December 2019
Event name :
Seventh annual meeting of the Belgian Society for Virology
Event organizer :
BELVIR committee
Event date :
19/12/2019
By request :
Yes
Available on ORBi :
since 13 January 2020

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