[en] Data on repeatability and optimal settings are needed when studying the influence of drugs on the intensity dependence of auditory evoked cortical potentials (IDAP). IDAP was recorded at intervals of 1, 2, and 24 h at two centers in 22 healthy volunteers. Settings were modified to compare fixed versus randomly varied stimulus repetition rate, as well as 30 Hz and 100 Hz low pass filters. Repeatability was assessed for different intervals and different settings. Group means did not differ between centers, the 2-h or 24-h retest, or when using different settings. We observed an order effect for the 1 h retest. Fixed repetition rate and the 30 Hz filter improved repeatability with still high intraindividual variability. IDAP group means can be compared between centers for retest intervals of 2 h and 24 h and different settings. Variability is too large to compare individuals.
Disciplines :
Neurology Neurosciences & behavior
Author, co-author :
Sandor, P. S.
Roon, K. I.
Ferrari, M. D.
van Dijk, J. G.
Schoenen, Jean ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Language :
English
Title :
Repeatability of the Intensity Dependence of Cortical Auditory Evoked Potentials in the Assessment of Cortical Information Processing
Wang W, Timsit-Berthier M, Schoenen J. Intensity dependence of auditory evoked potentials is pronounced in migraine: an indication of cortical potentiation and low serotonergic neurotransmission? Neurology 1996;46:1404-9
Áfra J, Proietti-Cecchini A, De Pasqua V, et al. Visual evoked potentials during long-lasting pattern-reversal stimulations in migraine. Brain 1998;121:233-41
Schoenen J. Cortical electrophysiology in migraine and possible pathogenetic implications. Clin Neurosci 1998;5:10-7
Proietti-Cecchini A, Áfra J, Schoenen J. Intensity dependence of the cortical auditory evoked potentials as a surrogate marker of CNS serotonin transmission in man: demonstration of a central effect for the 5HT1B/1D agonist zolmitriptan (311C90, Zomig). Cephalalgia 1997;17:849-54
Sándor PS, Áfra J, Mascia A, Schoenen J. Riboflavin and betablockers in prophylactic antimigraine therapy: differential effects on the intensity dependence of cortical auditory evoked potentials. Cephalalgia 1998;18:388
Hegerl U, Juckel G. Intensity dependence of auditory evoked potentials as an indicator of central serotonergic neurotransmission: a new hypothesis. Biol Psychiatry 1993;33:173-87
Hegerl U, Juckel G. Auditory evoked dipole source activity: indicator of central serotoninergic dysfunction in psychiatric patients? Pharmacopsychiatry 1994;27:75-8
Hegerl U, Juckel G, Schmidt LG, Rommelspacher H. Serotonergic ethanol effects and auditory evoked dipole activity in alcoholic and healthy subjects. Psychiatry Res 1996;63:47-55
Juckel G, Csépe V, Molnár M, Hegerl U, Karmos G. Intensity dependence of auditory evoked potentials in behaving cats. Electroencephalogr Clin Neurophysol 1996;100:527-37
Juckel G, Molnár M, Hegerl U, Csépe V, Karmos G. Auditory evoked potentials as indicator of brain serotonergic activity - first evidence in behaving cats. Biol Psychiatry 1997;41:1181-95
Ferrari MD, Saxena PR. On serotonin and migraine: a clinical and pharmacological review. Cephalalgia 1993;13:151-65
Silberstein SD. Serotonin (5HT) and migraine. Headache 1994;34:400-17
Schoenen J, Sándor PS. The headaches. In: Wall PD, Melzack R, editors. Textbook of pain, 4th edition. London: Churchill Livingstone, 1999. In press
Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986;8:307-10
Roon KI, Sándor PS, Schoonman GG, Lamers FPL, Schoenen J, et al. Auditory evoked potentials in the assessment of central nervous system effects of antimigraine drugs. Cephalalgia 1999;19:880-5
Hegerl U, Karnauchow I, Hermann WM, Müller-Oerlingschausen B. Intensity dependence of auditory evoked N1/P2 component and personality. Neuropsychobiology 1992;25:166-72
Hegerl U, Gallinat J, Mrowinski D. Intensity dependence of auditory evoked dipole source activity. Int J Psychophysiol 1994;17:1-13
Buchsbaum MS, Gillin JC, Pfefferbaum A. Effect of sleep stage and stimulus intensity on auditory average evoked responses. Psychophysiology 1975;12:707-12
Baribeau JC, Laurent J-P. The effect of selective attention on augmenting/intensity function on the early negative wave of AEPs. In: Johnson R, Rohrbaugh JW, Parasuraman R, editors. Current trends in event-related potential research. EEG suppl 40. Amsterdam: Elsevier, 1987:68-75