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From neurophysiology to genetics: cortical information processing in migraine underlies familial influences--a novel approach
Sandor, P. S.; Afra, J.; Proietti Cecchini, A. P. et al.
2000In Functional Neurology, 15 (Suppl 3), p. 68-72
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Keywords :
Adolescent; Adult; Auditory Cortex/physiology; Cerebral Cortex/physiology; Evoked Potentials, Auditory/physiology; Evoked Potentials, Visual/genetics/physiology; Female; Habituation, Psychophysiologic/genetics/physiology; Humans; Male; Mental Processes/physiology; Middle Aged; Migraine Disorders/genetics/physiopathology
Abstract :
[en] Migraine patients show impaired cortical information processing between attacks with deficient habituation of pattern-reversal visual evoked potentials (VEP), and strong intensity dependence of auditory cortical evoked potentials (IDAP). This could be a genetic trait as certain genetic patterns are known for evoked potentials in healthy subjects. VEP-habituation and IDAP were studied in 40 migraine patients, i.e. pairs of 20 parents and their children. We developed a novel approach based on Monte Carlo statistics to selectively assess vertical familial influences. Both groups, parents and children, were characterized by abnormal VEP-habituation and IDAP. However, similarity between related pairs was far more pronounced than similarity between unrelated pairs. Assessed with a novel statistical approach, familial influences proved to be highly significant in determining cortical information processing in migraineurs, thus supporting the important role of genetic factors.
Disciplines :
Neurosciences & behavior
Neurology
General & internal medicine
Author, co-author :
Sandor, P. S.
Afra, J.
Proietti Cecchini, A. P.
Albert, Adelin  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique
Schoenen, Jean  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Language :
English
Title :
From neurophysiology to genetics: cortical information processing in migraine underlies familial influences--a novel approach
Publication date :
2000
Journal title :
Functional Neurology
ISSN :
0393-5264
eISSN :
1971-3274
Publisher :
CIC Edizioni Internationali, Roma, Italy
Volume :
15
Issue :
Suppl 3
Pages :
68-72
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 September 2009

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